| pubmed-article:15541771 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15541771 | lifeskim:mentions | umls-concept:C1519740 | lld:lifeskim |
| pubmed-article:15541771 | lifeskim:mentions | umls-concept:C0282498 | lld:lifeskim |
| pubmed-article:15541771 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:15541771 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:15541771 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:15541771 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:15541771 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:15541771 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15541771 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:15541771 | pubmed:issue | 10-11 | lld:pubmed |
| pubmed-article:15541771 | pubmed:dateCreated | 2004-11-15 | lld:pubmed |
| pubmed-article:15541771 | pubmed:abstractText | An attenuated response to stress is characteristic of senescence. Heat shock (HS), a significant form of stress, is delayed and reduced in aging organisms. In the response to heat shock, heat shock factor 1 (HSF-1) is activated by trimerization of its monomeric subunits. This then initiates the transcription of a series of heat shock genes (hsp genes) that encode chaperone proteins protective against heat stress. Using a promoter binding electromobility shift assay (EMSA), we have found no activation of this transcription factor in the brains of old (36 months) rats in response to exposure to 41 degrees C for 1h while strong activation is elicited in young (6 months) animals. Since brains of young and old rats had approximately the same amount of HSF-1 subunits, we anticipated the presence of auxiliary regulatory factors essential for the activation of HSF-1 and the initiation of heat shock gene transcription. We describe three novel auxiliary factors--the proteins I-HSF [HSF inhibitor] and elongation factor-1 alpha (EF-1alpha) and a large non-coding RNA (HSR)--that participate in regulation and activation of HSF-1 in early stages of heat shock gene transcription. I-HSF inhibits trimerization of HSF-1 at normal temperatures. HSR and EF-1alpha form a complex with HSF-1 and facilitate its trimerization and binding to heat shock element (HSE) in the promoters of hsps. It is proposed that structural changes in any one or a combination of these factors in response to heat shock may contribute to the age-associated attenuation in the response to stress. | lld:pubmed |
| pubmed-article:15541771 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15541771 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15541771 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15541771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15541771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15541771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15541771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15541771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15541771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15541771 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15541771 | pubmed:issn | 0047-6374 | lld:pubmed |
| pubmed-article:15541771 | pubmed:author | pubmed-author:GershonDavidD | lld:pubmed |
| pubmed-article:15541771 | pubmed:author | pubmed-author:ShamovskyIlya... | lld:pubmed |
| pubmed-article:15541771 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15541771 | pubmed:volume | 125 | lld:pubmed |
| pubmed-article:15541771 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15541771 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15541771 | pubmed:pagination | 767-75 | lld:pubmed |
| pubmed-article:15541771 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15541771 | pubmed:meshHeading | pubmed-meshheading:15541771... | lld:pubmed |
| pubmed-article:15541771 | pubmed:meshHeading | pubmed-meshheading:15541771... | lld:pubmed |
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| pubmed-article:15541771 | pubmed:meshHeading | pubmed-meshheading:15541771... | lld:pubmed |
| pubmed-article:15541771 | pubmed:articleTitle | Novel regulatory factors of HSF-1 activation: facts and perspectives regarding their involvement in the age-associated attenuation of the heat shock response. | lld:pubmed |
| pubmed-article:15541771 | pubmed:affiliation | Department of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel. | lld:pubmed |
| pubmed-article:15541771 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15541771 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15541771 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15541771 | lld:pubmed |
