| pubmed-article:15537737 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15537737 | lifeskim:mentions | umls-concept:C0023185 | lld:lifeskim |
| pubmed-article:15537737 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:15537737 | lifeskim:mentions | umls-concept:C0028351 | lld:lifeskim |
| pubmed-article:15537737 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:15537737 | lifeskim:mentions | umls-concept:C0010531 | lld:lifeskim |
| pubmed-article:15537737 | lifeskim:mentions | umls-concept:C0005757 | lld:lifeskim |
| pubmed-article:15537737 | lifeskim:mentions | umls-concept:C0009647 | lld:lifeskim |
| pubmed-article:15537737 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:15537737 | lifeskim:mentions | umls-concept:C0205421 | lld:lifeskim |
| pubmed-article:15537737 | lifeskim:mentions | umls-concept:C0439858 | lld:lifeskim |
| pubmed-article:15537737 | lifeskim:mentions | umls-concept:C0443177 | lld:lifeskim |
| pubmed-article:15537737 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:15537737 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15537737 | pubmed:dateCreated | 2004-12-3 | lld:pubmed |
| pubmed-article:15537737 | pubmed:abstractText | The neurotransmitter norepinephrine (NE) has been shown to modulate cerebellar-dependent learning and memory. Lesions of the nucleus locus coeruleus or systemic blockade of noradrenergic receptors has been shown to delay the acquisition of several cerebellar-dependent learning tasks. To date, no studies have shown a direct involvement of cerebellar noradrenergic activity nor localized the post-synaptic response to cerebellar beta-noradrenergic receptor signaling. Using ipsilateral, localized infusions into cerebellar lobule HVI and interpositus (IP), we have established that blocking beta-noradrenergic receptors with propranolol significantly impairs acquisition of conditioned responses. Furthermore, interrupting activation of cAMP-dependent PKA in the cerebellum using Rp-cAMPS completely prevents acquisition. However, neither blocking beta-adrenergic receptors nor blocking PKA activation significantly interferes with performance of established conditioned responses when administered after the learned response is formed. | lld:pubmed |
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| pubmed-article:15537737 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15537737 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15537737 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15537737 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15537737 | pubmed:issn | 1072-0502 | lld:pubmed |
| pubmed-article:15537737 | pubmed:author | pubmed-author:BickfordPaula... | lld:pubmed |
| pubmed-article:15537737 | pubmed:author | pubmed-author:CartfordM... | lld:pubmed |
| pubmed-article:15537737 | pubmed:author | pubmed-author:SamecAmyA | lld:pubmed |
| pubmed-article:15537737 | pubmed:author | pubmed-author:FisterMathewM | lld:pubmed |
| pubmed-article:15537737 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15537737 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:15537737 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15537737 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15537737 | pubmed:pagination | 732-7 | lld:pubmed |
| pubmed-article:15537737 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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