| pubmed-article:15536181 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15536181 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:15536181 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:15536181 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15536181 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:15536181 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:15536181 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:15536181 | lifeskim:mentions | umls-concept:C0348080 | lld:lifeskim |
| pubmed-article:15536181 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15536181 | pubmed:dateCreated | 2004-11-10 | lld:pubmed |
| pubmed-article:15536181 | pubmed:abstractText | Evidence is mounting that hematopoietic stem cells (HSCs) play a critical role in bone marrow regeneration and tissue renewal, for which migration is an obvious prerequisite. Computer-aided analysis and a three-dimensional collagen matrix assay enabled us to analyze single-cell migratory characteristics of stromal cell-derived factor-1 alpha (SDF-1 alpha)-stimulated cord blood-derived HSCs. We defined and resolved specific migratory parameters in spontaneous and SDF-1 alpha-induced migration of these cells. The addition of interleukin 6 to the culture medium led to differential SDF-1 alpha-stimulated migratory response, which comprised a recruitment of nonmoving cells and an increase in speed and frequency of pauses but a decrease in pause duration. We were thus able to decipher the exact parameters that result in an increase in the migration of HSCs and demonstrate that extensive analysis of single-cell behavior is elementary in the study of stem cell migration. | lld:pubmed |
| pubmed-article:15536181 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15536181 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15536181 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15536181 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15536181 | pubmed:issn | 1066-5099 | lld:pubmed |
| pubmed-article:15536181 | pubmed:author | pubmed-author:HatzmannWolfg... | lld:pubmed |
| pubmed-article:15536181 | pubmed:author | pubmed-author:ZänkerKurt... | lld:pubmed |
| pubmed-article:15536181 | pubmed:author | pubmed-author:NiggemannBern... | lld:pubmed |
| pubmed-article:15536181 | pubmed:author | pubmed-author:DittmarThomas... | lld:pubmed |
| pubmed-article:15536181 | pubmed:author | pubmed-author:WeidtCorinnaC | lld:pubmed |
| pubmed-article:15536181 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15536181 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:15536181 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15536181 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15536181 | pubmed:pagination | 890-6 | lld:pubmed |
| pubmed-article:15536181 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15536181 | pubmed:meshHeading | pubmed-meshheading:15536181... | lld:pubmed |
| pubmed-article:15536181 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15536181 | pubmed:articleTitle | Differential effects of culture conditions on the migration pattern of stromal cell-derived factor-stimulated hematopoietic stem cells. | lld:pubmed |
| pubmed-article:15536181 | pubmed:affiliation | Institute of Immunology, University of Witten/Herdecke, Stockumer Str. 10, 58448 Witten, Germany. cweidt@uni-wh.de | lld:pubmed |
| pubmed-article:15536181 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15536181 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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