Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15536155rdf:typepubmed:Citationlld:pubmed
pubmed-article:15536155lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:15536155lifeskim:mentionsumls-concept:C0038317lld:lifeskim
pubmed-article:15536155lifeskim:mentionsumls-concept:C0916169lld:lifeskim
pubmed-article:15536155lifeskim:mentionsumls-concept:C1537561lld:lifeskim
pubmed-article:15536155lifeskim:mentionsumls-concept:C0014180lld:lifeskim
pubmed-article:15536155lifeskim:mentionsumls-concept:C0205065lld:lifeskim
pubmed-article:15536155lifeskim:mentionsumls-concept:C0165519lld:lifeskim
pubmed-article:15536155lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:15536155lifeskim:mentionsumls-concept:C0851285lld:lifeskim
pubmed-article:15536155lifeskim:mentionsumls-concept:C1879547lld:lifeskim
pubmed-article:15536155lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:15536155lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:15536155pubmed:issue2lld:pubmed
pubmed-article:15536155pubmed:dateCreated2005-2-8lld:pubmed
pubmed-article:15536155pubmed:abstractTextVarious matrix metalloproteinases (MMPs) participate in the menstrual breakdown of the human endometrium. MMP-9/gelatinase B is proposed as a major factor because it degrades many extracellular matrix constituents, including in the vasculature. Although globally under ovarian steroids control, endometrial MMP-9 seems expressed differently than other MMPs, and conflicting publications prevent a clear understanding of its regulation. We therefore quantified MMP-9 expression in the cycling human endometrium, defined its localization, and analyzed its regulation by estradiol and progesterone and by LEFTY-A/endometrial bleeding-associated factor in explant cultures. In fresh tissues, a major increase in MMP-9 mRNA expression occurred at menstruation, after a larger increase in LEFTY-A mRNA. MMP-9 was immunodetected in all cell types throughout the cycle, especially in foci of stromal cells during menstruation. MMP-9 synthesis by these cells was confirmed in cultured explants. In proliferative explants, ovarian steroids slightly decreased MMP-9 mRNA. They had no consistent effect on MMP-9 release in culture medium but strongly inhibited proMMP-9 activation. Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. We propose that endometrial MMP-9 activity is overall controlled by the ovarian steroids and locally adjusted through a network of modulators, including LEFTY-A.lld:pubmed
pubmed-article:15536155pubmed:languageenglld:pubmed
pubmed-article:15536155pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15536155pubmed:citationSubsetAIMlld:pubmed
pubmed-article:15536155pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15536155pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15536155pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15536155pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15536155pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15536155pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15536155pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15536155pubmed:statusMEDLINElld:pubmed
pubmed-article:15536155pubmed:monthFeblld:pubmed
pubmed-article:15536155pubmed:issn0021-972Xlld:pubmed
pubmed-article:15536155pubmed:authorpubmed-author:CourtoyPierre...lld:pubmed
pubmed-article:15536155pubmed:authorpubmed-author:HenrietPatric...lld:pubmed
pubmed-article:15536155pubmed:authorpubmed-author:CornetPatrici...lld:pubmed
pubmed-article:15536155pubmed:authorpubmed-author:GalantChristi...lld:pubmed
pubmed-article:15536155pubmed:authorpubmed-author:EeckhoutYvesYlld:pubmed
pubmed-article:15536155pubmed:authorpubmed-author:MarbaixEtienn...lld:pubmed
pubmed-article:15536155pubmed:issnTypePrintlld:pubmed
pubmed-article:15536155pubmed:volume90lld:pubmed
pubmed-article:15536155pubmed:ownerNLMlld:pubmed
pubmed-article:15536155pubmed:authorsCompleteYlld:pubmed
pubmed-article:15536155pubmed:pagination1001-11lld:pubmed
pubmed-article:15536155pubmed:dateRevised2008-11-21lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:meshHeadingpubmed-meshheading:15536155...lld:pubmed
pubmed-article:15536155pubmed:year2005lld:pubmed
pubmed-article:15536155pubmed:articleTitleRegulation of matrix metalloproteinase-9/gelatinase B expression and activation by ovarian steroids and LEFTY-A/endometrial bleeding-associated factor in the human endometrium.lld:pubmed
pubmed-article:15536155pubmed:affiliationCell Biology Unit, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, B-1200 Brussels, Belgium.lld:pubmed
pubmed-article:15536155pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15536155pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:4318entrezgene:pubmedpubmed-article:15536155lld:entrezgene
entrez-gene:7044entrezgene:pubmedpubmed-article:15536155lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15536155lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15536155lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15536155lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15536155lld:pubmed