| pubmed-article:15535835 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C1426208 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15535835 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15535835 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15535835 | pubmed:dateCreated | 2004-11-10 | lld:pubmed |
| pubmed-article:15535835 | pubmed:abstractText | IL-10 has been shown to block the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway. We found that peripheral blood CD4+ T cells from patients with active rheumatoid arthritis (RA) were able to produce greater amounts of interferon gamma after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 than were normal control CD4+ T cells, although their surface expression of the type 1 IL-10 receptor was increased. The phosphorylation of signal transducer and activator of transcription 3 was sustained in both blood and synovial tissue CD4+ T cells of RA, but it was not augmented by the presence of 1 ng/ml IL-10. Sera from RA patients induced signal transducer and activator of transcription 3 phosphorylation in normal CD4+ T cells, which was mostly abolished by neutralizing anti-IL-6 antibody. Preincubation of normal CD4+ T cells with IL-6 reduced IL-10-mediated inhibition of interferon gamma production. Blood CD4+ T cells from RA patients contained higher levels of suppressor of cytokine signaling 1 but lower levels of suppressor of cytokine signaling 3 mRNA compared with control CD4+ T cells, as determined by real-time PCR. These results indicate that RA CD4+ T cells become resistant to the immunosuppressive effect of IL-10 before migration into synovial tissue, and this impaired IL-10 signaling may be associated with sustained signal transducer and activator of transcription 3 activation and suppressor of cytokine signaling 1 induction. | lld:pubmed |
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| pubmed-article:15535835 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15535835 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15535835 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15535835 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15535835 | pubmed:issn | 1478-6362 | lld:pubmed |
| pubmed-article:15535835 | pubmed:author | pubmed-author:YamamuraMasah... | lld:pubmed |
| pubmed-article:15535835 | pubmed:author | pubmed-author:MakinoHirofum... | lld:pubmed |
| pubmed-article:15535835 | pubmed:author | pubmed-author:OkamotoAkiraA | lld:pubmed |
| pubmed-article:15535835 | pubmed:author | pubmed-author:AitaTetsushiT | lld:pubmed |
| pubmed-article:15535835 | pubmed:author | pubmed-author:IwahashiMitsu... | lld:pubmed |
| pubmed-article:15535835 | pubmed:author | pubmed-author:YamanaJiroJ | lld:pubmed |
| pubmed-article:15535835 | pubmed:author | pubmed-author:SunahoriKatsu... | lld:pubmed |
| pubmed-article:15535835 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15535835 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:15535835 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15535835 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15535835 | pubmed:pagination | R567-77 | lld:pubmed |
| pubmed-article:15535835 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15535835 | pubmed:meshHeading | pubmed-meshheading:15535835... | lld:pubmed |
| pubmed-article:15535835 | pubmed:meshHeading | pubmed-meshheading:15535835... | lld:pubmed |
