| pubmed-article:15531912 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15531912 | lifeskim:mentions | umls-concept:C1705065 | lld:lifeskim |
| pubmed-article:15531912 | lifeskim:mentions | umls-concept:C2239176 | lld:lifeskim |
| pubmed-article:15531912 | lifeskim:mentions | umls-concept:C0544886 | lld:lifeskim |
| pubmed-article:15531912 | lifeskim:mentions | umls-concept:C0079380 | lld:lifeskim |
| pubmed-article:15531912 | lifeskim:mentions | umls-concept:C0332183 | lld:lifeskim |
| pubmed-article:15531912 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15531912 | pubmed:dateCreated | 2005-1-7 | lld:pubmed |
| pubmed-article:15531912 | pubmed:abstractText | Evidence exists that alterations of the genes encoding apoptosis-related proteins contribute to either development or progression of human cancers. Caspase-8 plays a crucial role in the initiation phase of apoptosis. To explore the possibility that the genetic alteration of caspase-8 gene is involved in the development of hepatocellular carcinomas (HCCs), we have analysed the entire coding region of human caspase-8 gene for the detection of somatic mutations by polymerase chain reaction-single-strand conformation polymorphism in 69 HCCs with low-grade dysplastic nodule (LGDN, n=2) or high-grade dysplastic nodule (HGDN, n=2) or without any dysplastic nodules (n=65). Overall, we detected a total of nine somatic mutations in 69 HCCs (13.0%). Interestingly, all of the nine mutations were an identical frameshift mutation with two base-pair deletion (1225_1226delTG), which would result in a premature termination of amino-acid synthesis in the p10 protease subunit. In a patient sample, we detected the 1225_1226delTG mutation both in HCC and LDGN lesions, suggesting that caspase-8 mutation could be involved in the early stage of HCC carcinogenesis. We expressed the tumor-derived caspase-8 mutant in the cells and found that the mutant abolished cell death activity of caspase-8. Our data indicate that caspase-8 gene is frequently mutated in HCC and the majority of the mutations may be the frameshift mutation 1225_1226delTG. Also, the data suggest that caspase-8 gene mutation might lead to the loss of its cell death function and contribute to the pathogenesis of HCC. | lld:pubmed |
| pubmed-article:15531912 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15531912 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15531912 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15531912 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15531912 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15531912 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15531912 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15531912 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15531912 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15531912 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15531912 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15531912 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:15531912 | pubmed:author | pubmed-author:ParkWon... | lld:pubmed |
| pubmed-article:15531912 | pubmed:author | pubmed-author:LeeSug... | lld:pubmed |
| pubmed-article:15531912 | pubmed:author | pubmed-author:YooNam JinNJ | lld:pubmed |
| pubmed-article:15531912 | pubmed:author | pubmed-author:LeeJung... | lld:pubmed |
| pubmed-article:15531912 | pubmed:author | pubmed-author:KimSu YoungSY | lld:pubmed |
| pubmed-article:15531912 | pubmed:author | pubmed-author:KimSang HoSH | lld:pubmed |
| pubmed-article:15531912 | pubmed:author | pubmed-author:LeeJong WooJW | lld:pubmed |
| pubmed-article:15531912 | pubmed:author | pubmed-author:SoungYoung... | lld:pubmed |
| pubmed-article:15531912 | pubmed:author | pubmed-author:NamSuk WooSW | lld:pubmed |
| pubmed-article:15531912 | pubmed:author | pubmed-author:SungYong... | lld:pubmed |
| pubmed-article:15531912 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15531912 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:15531912 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:15531912 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15531912 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15531912 | pubmed:pagination | 141-7 | lld:pubmed |
| pubmed-article:15531912 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:meshHeading | pubmed-meshheading:15531912... | lld:pubmed |
| pubmed-article:15531912 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15531912 | pubmed:articleTitle | Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas. | lld:pubmed |
| pubmed-article:15531912 | pubmed:affiliation | Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea. | lld:pubmed |
| pubmed-article:15531912 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15531912 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:841 | entrezgene:pubmed | pubmed-article:15531912 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15531912 | lld:entrezgene |
| lhgdn:association:4209 | lhgdn:found_in | pubmed-article:15531912 | lld:lhgdn |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15531912 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15531912 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15531912 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15531912 | lld:pubmed |
