| pubmed-article:15531795 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15531795 | lifeskim:mentions | umls-concept:C0022262 | lld:lifeskim |
| pubmed-article:15531795 | lifeskim:mentions | umls-concept:C0031453 | lld:lifeskim |
| pubmed-article:15531795 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:15531795 | lifeskim:mentions | umls-concept:C0456603 | lld:lifeskim |
| pubmed-article:15531795 | lifeskim:mentions | umls-concept:C0037813 | lld:lifeskim |
| pubmed-article:15531795 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:15531795 | lifeskim:mentions | umls-concept:C0008565 | lld:lifeskim |
| pubmed-article:15531795 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15531795 | pubmed:dateCreated | 2004-11-8 | lld:pubmed |
| pubmed-article:15531795 | pubmed:abstractText | The application of time-of-flight mass spectrometry to isotope ratio measurements has been limited by the relatively low dynamic range of the time-to-digital converter detectors available on commercial LC/ToF-MS systems. Here we report the measurement of phenylalanine isotope ratio enrichment by using a new LC/ToF-MS system with wide dynamic range. Underivatized phenylalanine was injected onto a C18 column directly with 0.1% formic acid/acetonitrile as the mobile phase. The optimal instrument parameters for the time-of-flight mass spectrometer were determined by tuning the instrument with a phenylalanine standard. The accuracy of the isotope enrichment measurement was determined by the injection of standard solutions with known isotope ratios ranging from 0.02% to 9.2%. A plot of the results against the theoretical values gave a linear curve with R2 of 0.9999. The coefficient of variation for the isotope ratio measurement was below 2%. The method is simple, rapid, and accurate and presents an attractive alternative to traditional GC/MS applications. | lld:pubmed |
| pubmed-article:15531795 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15531795 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15531795 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15531795 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15531795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15531795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15531795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15531795 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15531795 | pubmed:issn | 1469-0667 | lld:pubmed |
| pubmed-article:15531795 | pubmed:author | pubmed-author:WolfeRobert... | lld:pubmed |
| pubmed-article:15531795 | pubmed:author | pubmed-author:ZhangXiao-Jun... | lld:pubmed |
| pubmed-article:15531795 | pubmed:author | pubmed-author:WuZhanpinZ | lld:pubmed |
| pubmed-article:15531795 | pubmed:author | pubmed-author:CodyRobert... | lld:pubmed |
| pubmed-article:15531795 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15531795 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:15531795 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15531795 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15531795 | pubmed:pagination | 619-23 | lld:pubmed |
| pubmed-article:15531795 | pubmed:dateRevised | 2005-8-8 | lld:pubmed |
| pubmed-article:15531795 | pubmed:meshHeading | pubmed-meshheading:15531795... | lld:pubmed |
| pubmed-article:15531795 | pubmed:meshHeading | pubmed-meshheading:15531795... | lld:pubmed |
| pubmed-article:15531795 | pubmed:meshHeading | pubmed-meshheading:15531795... | lld:pubmed |
| pubmed-article:15531795 | pubmed:meshHeading | pubmed-meshheading:15531795... | lld:pubmed |
| pubmed-article:15531795 | pubmed:meshHeading | pubmed-meshheading:15531795... | lld:pubmed |
| pubmed-article:15531795 | pubmed:meshHeading | pubmed-meshheading:15531795... | lld:pubmed |
| pubmed-article:15531795 | pubmed:meshHeading | pubmed-meshheading:15531795... | lld:pubmed |
| pubmed-article:15531795 | pubmed:meshHeading | pubmed-meshheading:15531795... | lld:pubmed |
| pubmed-article:15531795 | pubmed:meshHeading | pubmed-meshheading:15531795... | lld:pubmed |
| pubmed-article:15531795 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15531795 | pubmed:articleTitle | Determination of phenylalanine isotope ratio enrichment by liquid chromatography/time- of-flight mass spectrometry. | lld:pubmed |
| pubmed-article:15531795 | pubmed:affiliation | Analytical Instrument Division, JEOL USA, Inc., 11 Dearborn Road, Peabody, MA 01960, USA. zwu@jeol.com | lld:pubmed |
| pubmed-article:15531795 | pubmed:publicationType | Journal Article | lld:pubmed |
