| pubmed-article:15530508 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15530508 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:15530508 | lifeskim:mentions | umls-concept:C0034719 | lld:lifeskim |
| pubmed-article:15530508 | lifeskim:mentions | umls-concept:C0911014 | lld:lifeskim |
| pubmed-article:15530508 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15530508 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15530508 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15530508 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15530508 | lifeskim:mentions | umls-concept:C0204695 | lld:lifeskim |
| pubmed-article:15530508 | lifeskim:mentions | umls-concept:C0682770 | lld:lifeskim |
| pubmed-article:15530508 | lifeskim:mentions | umls-concept:C2709063 | lld:lifeskim |
| pubmed-article:15530508 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15530508 | pubmed:dateCreated | 2004-11-8 | lld:pubmed |
| pubmed-article:15530508 | pubmed:abstractText | Ghrelin is a new orexigenic and adipogenic peptide primarily produced by the stomach and the hypothalamus. In the present experiment, we determined the circulating ghrelin levels in 60-week old fa/fa Zucker rats with a well-established obesity (n = 12) and in their lean (FA/FA) counterparts (n = 12). We also tested the feeding response of both groups to intra-peritoneal (I.P.) injection of ghrelin agonist and antagonist. Obese rats ate significantly more than the lean rats (21.7 +/- 1.1 vs. 18.3 +/- 0.3 g/day; p < 0.01). Their plasma ghrelin concentration was 35% higher than that in the lean homozygous rats (p < 0.025). GHRP-6 (1 mg/kg I.P, a GHS-R agonist) stimulated food intake in lean but not in obese rats (p < 0.01), whereas [D-Lys)]-GHRP-6 (12 mg/kg I.P., a GHS-R antagonist) decreased food intake in both groups (p < 0.0001). These results indicate that the obese Zucker rat is characterized by an increase in plasma ghrelin concentrations and by an attenuated response to a GHS-R agonist. They support a role for ghrelin in the development of obesity in the absence of leptin signaling. | lld:pubmed |
| pubmed-article:15530508 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15530508 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15530508 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15530508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15530508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15530508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15530508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15530508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15530508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15530508 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15530508 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15530508 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:15530508 | pubmed:author | pubmed-author:Stricker-Kron... | lld:pubmed |
| pubmed-article:15530508 | pubmed:author | pubmed-author:RichySébastie... | lld:pubmed |
| pubmed-article:15530508 | pubmed:author | pubmed-author:BeckBernardB | lld:pubmed |
| pubmed-article:15530508 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15530508 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:15530508 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:15530508 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15530508 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15530508 | pubmed:pagination | 473-8 | lld:pubmed |
| pubmed-article:15530508 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:15530508 | pubmed:meshHeading | pubmed-meshheading:15530508... | lld:pubmed |
| pubmed-article:15530508 | pubmed:meshHeading | pubmed-meshheading:15530508... | lld:pubmed |
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| pubmed-article:15530508 | pubmed:meshHeading | pubmed-meshheading:15530508... | lld:pubmed |
| pubmed-article:15530508 | pubmed:meshHeading | pubmed-meshheading:15530508... | lld:pubmed |
| pubmed-article:15530508 | pubmed:meshHeading | pubmed-meshheading:15530508... | lld:pubmed |
| pubmed-article:15530508 | pubmed:meshHeading | pubmed-meshheading:15530508... | lld:pubmed |
| pubmed-article:15530508 | pubmed:meshHeading | pubmed-meshheading:15530508... | lld:pubmed |
| pubmed-article:15530508 | pubmed:meshHeading | pubmed-meshheading:15530508... | lld:pubmed |
| pubmed-article:15530508 | pubmed:meshHeading | pubmed-meshheading:15530508... | lld:pubmed |
| pubmed-article:15530508 | pubmed:meshHeading | pubmed-meshheading:15530508... | lld:pubmed |
| pubmed-article:15530508 | pubmed:meshHeading | pubmed-meshheading:15530508... | lld:pubmed |
| pubmed-article:15530508 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15530508 | pubmed:articleTitle | Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats. | lld:pubmed |
| pubmed-article:15530508 | pubmed:affiliation | UHP/EA 3453 - IFR 111-Systèmes Neuromodulateurs des Comportements Ingestifs-38, rue Lionnois 54000 Nancy, France. | lld:pubmed |
| pubmed-article:15530508 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15530508 | lld:pubmed |
