| pubmed-article:15529263 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C2911648 | lld:lifeskim |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C1963724 | lld:lifeskim |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C1880019 | lld:lifeskim |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:15529263 | lifeskim:mentions | umls-concept:C1719797 | lld:lifeskim |
| pubmed-article:15529263 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15529263 | pubmed:dateCreated | 2004-11-5 | lld:pubmed |
| pubmed-article:15529263 | pubmed:abstractText | To characterize newly arising replication of human immunodeficiency virus (HIV) type 1 in vivo at the cellular level, distinct viral RNA species in peripheral blood mononuclear cells (PBMCs) from HIV-1-infected patients were monitored during 2 weeks of structured treatment interruption (STI). HIV-1 RNA encoding tat/rev and PBMC-associated virions were almost completely depleted during antiretroviral therapy and emerged simultaneously after 2 weeks of STI, thus specifically reflecting productive viral infection at the cellular level. The magnitude of these correlates of reappearing cellular viral replication was predicted by during-therapy levels of nef transcripts in PBMCs. Significant rebound of plasma viremia, representing the progeny of a broader range of anatomical compartments, preceded and predicted productive infection in PBMCs. Thus, cellular viral rebound in PBMCs likely was primed before STI by the expression of nef in HIV-1-infected PBMCs that lacked virion production and was subsequently triggered by the plasma viremia that preceded the recurrence of productively infected PBMCs. | lld:pubmed |
| pubmed-article:15529263 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15529263 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15529263 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15529263 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15529263 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15529263 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:15529263 | pubmed:author | pubmed-author:Swiss HIV... | lld:pubmed |
| pubmed-article:15529263 | pubmed:author | pubmed-author:HirschelBerna... | lld:pubmed |
| pubmed-article:15529263 | pubmed:author | pubmed-author:WeberRainerR | lld:pubmed |
| pubmed-article:15529263 | pubmed:author | pubmed-author:FischerMarekM | lld:pubmed |
| pubmed-article:15529263 | pubmed:author | pubmed-author:BleiberGabrie... | lld:pubmed |
| pubmed-article:15529263 | pubmed:author | pubmed-author:JoosBedaB | lld:pubmed |
| pubmed-article:15529263 | pubmed:author | pubmed-author:GünthardHuldr... | lld:pubmed |
| pubmed-article:15529263 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15529263 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15529263 | pubmed:volume | 190 | lld:pubmed |
| pubmed-article:15529263 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15529263 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15529263 | pubmed:pagination | 1979-88 | lld:pubmed |
| pubmed-article:15529263 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15529263 | pubmed:meshHeading | pubmed-meshheading:15529263... | lld:pubmed |
| pubmed-article:15529263 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15529263 | pubmed:articleTitle | Cellular viral rebound after cessation of potent antiretroviral therapy predicted by levels of multiply spliced HIV-1 RNA encoding nef. | lld:pubmed |
| pubmed-article:15529263 | pubmed:affiliation | Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital Zurich, CH-8091 Zurich, Switzerland. marek.fischer@usz.ch | lld:pubmed |
| pubmed-article:15529263 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15529263 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15529263 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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