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pubmed-article:15527704rdf:typepubmed:Citationlld:pubmed
pubmed-article:15527704lifeskim:mentionsumls-concept:C0085278lld:lifeskim
pubmed-article:15527704pubmed:issue6lld:pubmed
pubmed-article:15527704pubmed:dateCreated2004-11-5lld:pubmed
pubmed-article:15527704pubmed:abstractTextThe description of antiphospholipid syndrome (APS) is vascular thrombosis and/or pregnancy morbidity occurring in persons with antiphospholipid antibodies (aPL). However, because of an unclear etiopathogenesis and the heterogeneous nature of aPL and of aPL-related clinical manifestations, a single, unambiguous definition of APS does not exist. In this paper, we describe a structured approach to APS, discuss the controversies, and offer descriptions of APS that include: an autoimmune systemic disease with a spectrum of (mostly thrombotic) clinical manifestations, an overdiagnosed disease when aPL is present but has no proven direct causative role in the clinical manifestations, and a disease of controversies that requires clarification of etiology and mechanisms and risk-stratified controlled clinical studies.lld:pubmed
pubmed-article:15527704pubmed:languageenglld:pubmed
pubmed-article:15527704pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
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pubmed-article:15527704pubmed:statusMEDLINElld:pubmed
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pubmed-article:15527704pubmed:issn1523-3774lld:pubmed
pubmed-article:15527704pubmed:authorpubmed-author:ErkanDorukDlld:pubmed
pubmed-article:15527704pubmed:authorpubmed-author:LockshinMicha...lld:pubmed
pubmed-article:15527704pubmed:issnTypePrintlld:pubmed
pubmed-article:15527704pubmed:volume6lld:pubmed
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pubmed-article:15527704pubmed:authorsCompleteYlld:pubmed
pubmed-article:15527704pubmed:pagination451-7lld:pubmed
pubmed-article:15527704pubmed:dateRevised2005-11-16lld:pubmed
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pubmed-article:15527704pubmed:year2004lld:pubmed
pubmed-article:15527704pubmed:articleTitleWhat is antiphospholipid syndrome?lld:pubmed
pubmed-article:15527704pubmed:affiliationDepartment of Rheumatolopgy, Hospital for Special Surgery, 535 E 70th Street, New York, NY 10021, USA. derkan@pol.netlld:pubmed
pubmed-article:15527704pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15527704pubmed:publicationTypeReviewlld:pubmed
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