| pubmed-article:1552747 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1552747 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1552747 | lifeskim:mentions | umls-concept:C1953345 | lld:lifeskim |
| pubmed-article:1552747 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1552747 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:1552747 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1552747 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1552747 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1552747 | pubmed:dateCreated | 1992-4-24 | lld:pubmed |
| pubmed-article:1552747 | pubmed:abstractText | The Evi-1 zinc-finger protein gene is normally not expressed in hematopoietic cells. However, high Evi-1 mRNA expression has been reported in mouse myeloblastic leukemias, due to transcriptional activation by proviral integration in either the Fim-3 or Evi-1 loci. The human Evi-1 gene is located on chromosome 3q24-q28. In this paper three examples are presented of human acute myelogenous leukemias presenting common characteristics: (i) high Evi-1 mRNA expression; (ii) chromosomal abnormalities t(3;3)(q21;q26) or inv(3;3)(q21-22;q26); and (iii) high platelet counts and dystrophic megakaryocytes. Thirty-four other patients with hematological malignancies, among which 11 had chromosomal rearrangements in the 3q24-q28 region did not exhibit such abnormalities. Of the 13 permanent hemopoietic cell lines tested, Evi-1 RNA expression was found in HEL and K-562 cell lines. Weak Evi-1 expression was also seen in fibroblasts and lung cells. This expression was affected neither in skin cells from a patient with a 3q27 constitutional translocation nor in a lung epithelioma cell line containing an excess of chromosome 3 long arm. Ectopic strong expression of Evi-1 in human leukemias could define an uncommon subclass of acute myelogenous leukemias with translocations involving the 3q25-28 chromosomal domain and abnormal megakaryopoiesis. | lld:pubmed |
| pubmed-article:1552747 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1552747 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1552747 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1552747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1552747 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1552747 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1552747 | pubmed:issn | 0887-6924 | lld:pubmed |
| pubmed-article:1552747 | pubmed:author | pubmed-author:BergerRR | lld:pubmed |
| pubmed-article:1552747 | pubmed:author | pubmed-author:GisselbrechtS... | lld:pubmed |
| pubmed-article:1552747 | pubmed:author | pubmed-author:DreyfusFF | lld:pubmed |
| pubmed-article:1552747 | pubmed:author | pubmed-author:FichelsonSS | lld:pubmed |
| pubmed-article:1552747 | pubmed:author | pubmed-author:MelloPP | lld:pubmed |
| pubmed-article:1552747 | pubmed:author | pubmed-author:MicleaJ MJM | lld:pubmed |
| pubmed-article:1552747 | pubmed:author | pubmed-author:BastardCC | lld:pubmed |
| pubmed-article:1552747 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1552747 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:1552747 | pubmed:geneSymbol | Evi-1 | lld:pubmed |
| pubmed-article:1552747 | pubmed:geneSymbol | BuChE | lld:pubmed |
| pubmed-article:1552747 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1552747 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1552747 | pubmed:pagination | 93-9 | lld:pubmed |
| pubmed-article:1552747 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:meshHeading | pubmed-meshheading:1552747-... | lld:pubmed |
| pubmed-article:1552747 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1552747 | pubmed:articleTitle | Evi-1 expression in leukemic patients with rearrangements of the 3q25-q28 chromosomal region. | lld:pubmed |
| pubmed-article:1552747 | pubmed:affiliation | Laboratoire d'Immunologie et Oncologie des Maladies Rétrovirales, INSERM U152, Hôpital Cochin, Paris, France. | lld:pubmed |
| pubmed-article:1552747 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1552747 | lld:pubmed |
