| pubmed-article:1552285 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:1552285 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:1552285 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:1552285 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1552285 | lifeskim:mentions | umls-concept:C0026565 | lld:lifeskim |
| pubmed-article:1552285 | lifeskim:mentions | umls-concept:C0019627 | lld:lifeskim |
| pubmed-article:1552285 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:1552285 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:1552285 | lifeskim:mentions | umls-concept:C0449297 | lld:lifeskim |
| pubmed-article:1552285 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:1552285 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:1552285 | lifeskim:mentions | umls-concept:C0205421 | lld:lifeskim |
| pubmed-article:1552285 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1552285 | pubmed:dateCreated | 1992-4-24 | lld:pubmed |
| pubmed-article:1552285 | pubmed:abstractText | To investigate the role of CD8+ T lymphocytes in recovery from influenza pneumonia, we used transgenic mice either homozygous (-/-) or heterozygous (+/-) for beta 2-microglobulin (beta 2-M) gene disruption. These mice lack major histocompatibility complex-restricted class I (CD8+) T cells. We found that after challenge with a nonlethal influenza virus, the beta 2-M (-/-) mice had significantly delayed pulmonary viral clearance. Furthermore, after challenge with a more virulent influenza virus, the beta 2-M (-/-) mice had a significantly higher mortality rate than did control mice. Thus, CD8+ T cells are important in recovery from virulent influenza infections, but other host defense mechanisms can clear the respiratory tract of more benign infections. | lld:pubmed |
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| pubmed-article:1552285 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1552285 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1552285 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1552285 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1552285 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1552285 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:1552285 | pubmed:author | pubmed-author:SmallP APAJr | lld:pubmed |
| pubmed-article:1552285 | pubmed:author | pubmed-author:ZhangLL | lld:pubmed |
| pubmed-article:1552285 | pubmed:author | pubmed-author:BenderB SBS | lld:pubmed |
| pubmed-article:1552285 | pubmed:author | pubmed-author:CroghanTT | lld:pubmed |
| pubmed-article:1552285 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1552285 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1552285 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:1552285 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1552285 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1552285 | pubmed:pagination | 1143-5 | lld:pubmed |
| pubmed-article:1552285 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1552285 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1552285 | pubmed:articleTitle | Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. | lld:pubmed |
| pubmed-article:1552285 | pubmed:affiliation | Department of Medicine, University of Florida College of Medicine, Gainesville. | lld:pubmed |
| pubmed-article:1552285 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1552285 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1552285 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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