| pubmed-article:15519195 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15519195 | lifeskim:mentions | umls-concept:C0042449 | lld:lifeskim |
| pubmed-article:15519195 | lifeskim:mentions | umls-concept:C0145779 | lld:lifeskim |
| pubmed-article:15519195 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:15519195 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:15519195 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:15519195 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:15519195 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15519195 | pubmed:dateCreated | 2004-11-2 | lld:pubmed |
| pubmed-article:15519195 | pubmed:abstractText | Immediate loss of thrombomodulin activity in the endothelium of vein grafts has been demonstrated during 90 min exposure to arterial circulation; this loss of activity is ascribed as an important cause of early thrombosis. Conventional ex vivo gene transfection after vein harvest cannot cover this acute period immediately after implantation. We have established a highly efficient non-viral gene therapy protocol utilizing modified transferrin receptor-facilitated gene transfer. Using this technique, we examined whether in vivo thrombomodulin gene therapy, directed to the endothelium of rat veins 2 days prior to grafting, may prevent thromboresistance impairment of vein grafts under simulated arterial circulation. | lld:pubmed |
| pubmed-article:15519195 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15519195 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15519195 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15519195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15519195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15519195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15519195 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15519195 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15519195 | pubmed:issn | 1010-7940 | lld:pubmed |
| pubmed-article:15519195 | pubmed:author | pubmed-author:ShichiriMasay... | lld:pubmed |
| pubmed-article:15519195 | pubmed:author | pubmed-author:HirosawaShins... | lld:pubmed |
| pubmed-article:15519195 | pubmed:author | pubmed-author:SunamoriMakot... | lld:pubmed |
| pubmed-article:15519195 | pubmed:author | pubmed-author:KoyamaTakatos... | lld:pubmed |
| pubmed-article:15519195 | pubmed:author | pubmed-author:TabuchiNoriyu... | lld:pubmed |
| pubmed-article:15519195 | pubmed:author | pubmed-author:ShibamiyaAyaA | lld:pubmed |
| pubmed-article:15519195 | pubmed:author | pubmed-author:NakazawaFumie... | lld:pubmed |
| pubmed-article:15519195 | pubmed:author | pubmed-author:ChungJihwaJ | lld:pubmed |
| pubmed-article:15519195 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15519195 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:15519195 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15519195 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15519195 | pubmed:pagination | 995-1001 | lld:pubmed |
| pubmed-article:15519195 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:meshHeading | pubmed-meshheading:15519195... | lld:pubmed |
| pubmed-article:15519195 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15519195 | pubmed:articleTitle | Non-viral in vivo thrombomodulin gene transfer prevents early loss of thromboresistance of grafted veins. | lld:pubmed |
| pubmed-article:15519195 | pubmed:affiliation | Department of Cardio-Thoracic Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan. | lld:pubmed |
| pubmed-article:15519195 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15519195 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:83580 | entrezgene:pubmed | pubmed-article:15519195 | lld:entrezgene |
