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pubmed-article:15518908pubmed:dateCreated2004-11-2lld:pubmed
pubmed-article:15518908pubmed:abstractTextIn the present work, PAC1-R (G-protein-coupled receptor specific for PACAP) was detected on cells in the normal thymus. Immunohistochemically PAC1-R was expressed strongly in stromal cells of the thymic medulla. Positive cells were also observed in the thymus of fetal and old adult rats. After 8 Gy irradiation to 9-week-old rats, PAC1-R expressions in the thymus decreased and almost recovered by day 21. The expression of PAC1-R mRNA was weak in the thymus and decreased further after irradiation. The expression almost recovered by day 28. Hip and hip/hop variants, which were not expressed in the normal thymus, were expressed in the thymus on days 3, 5 and 21 after irradiation. The expressions of IL-6 and IL-10 tended to increase initially after irradiation then decreased. Histologically, the thymic structures were destroyed on day 3 after irradiation and the thymus almost recovered by day 21. Thus PACAP is thought to be one of the important factors for cross-talk between cells involved in thymic regeneration.lld:pubmed
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pubmed-article:15518908pubmed:authorpubmed-author:FunahashiHisa...lld:pubmed
pubmed-article:15518908pubmed:authorpubmed-author:ShiodaSeijiSlld:pubmed
pubmed-article:15518908pubmed:authorpubmed-author:MizutaniNorik...lld:pubmed
pubmed-article:15518908pubmed:authorpubmed-author:TokudaNobukoNlld:pubmed
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pubmed-article:15518908pubmed:authorpubmed-author:HamasakiKeiko...lld:pubmed
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pubmed-article:15518908pubmed:pagination167-72lld:pubmed
pubmed-article:15518908pubmed:dateRevised2005-11-17lld:pubmed
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pubmed-article:15518908pubmed:year2004lld:pubmed
pubmed-article:15518908pubmed:articleTitleExpression of PAC1 receptor in rat thymus after irradiation.lld:pubmed
pubmed-article:15518908pubmed:affiliationDepartment of Human Science, Yamaguchi University School of Medicine, Ube 755-8505, Japan. toku@yamaguchi-u.ac.jplld:pubmed
pubmed-article:15518908pubmed:publicationTypeJournal Articlelld:pubmed