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pubmed-article:15516267pubmed:abstractTextMucosal delivery of therapeutic protein drugs or vaccines is actively investigated, in order to improve bioavailability and avoid side effects associated with systemic administration. Orally administered bacteria, engineered to produce anti-inflammatory cytokines (IL-10, IL-1Ra), have shown localised ameliorating effects in inflammatory gastro-intestinal conditions. However, the possible systemic effects of mucosally delivered recombinant bacteria have not been investigated.lld:pubmed
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pubmed-article:15516267pubmed:articleTitleMucosal delivery of anti-inflammatory IL-1Ra by sporulating recombinant bacteria.lld:pubmed
pubmed-article:15516267pubmed:affiliationInpharzam Ricerche SA, Zambon Group, Via ai Söi, CH-6807 Taverne, Switzerland. Stefano.Porzio@ZambonGroup.com <Stefano.Porzio@ZambonGroup.com>lld:pubmed
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