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pubmed-article:15510836pubmed:abstractTextAn increase in the presence of the Ph-negative, trisomy 8 clone has been reported in chronic myelogenous leukemia (CML) under imatinib therapy, but any impact of the clone on patient prognosis remains uncertain. We report here on a 42-year-old male with CML who received imatinib after failure of interferon-alpha therapy. A chromosomal analysis revealed 18/20 trisomy 8 in bone marrow at 10 months of imatinib administration. Continuing imatinib at 300 mg daily resulted in a decrease in the number of trisomy 8 clones as well as the disappearance of Ph clone. Furthermore, the patient's pancytopenia was gradually improved. Imatinib therapy could be continued even with the emergence of trisomy 8.lld:pubmed
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pubmed-article:15510836pubmed:authorpubmed-author:KimuraFumihik...lld:pubmed
pubmed-article:15510836pubmed:authorpubmed-author:MotoyoshiKazu...lld:pubmed
pubmed-article:15510836pubmed:authorpubmed-author:KobayashiShin...lld:pubmed
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pubmed-article:15510836pubmed:authorpubmed-author:IkedaTakashiTlld:pubmed
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pubmed-article:15510836pubmed:authorpubmed-author:TorikaiHiroki...lld:pubmed
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pubmed-article:15510836pubmed:volume45lld:pubmed
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pubmed-article:15510836pubmed:pagination1058-60lld:pubmed
pubmed-article:15510836pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:15510836pubmed:year2004lld:pubmed
pubmed-article:15510836pubmed:articleTitle[Emergence and decrement of Ph-negative clone with trisomy 8 in CML during imatinib therapy].lld:pubmed
pubmed-article:15510836pubmed:affiliationThird Department of Internal Medicine, National Defense Medical College.lld:pubmed
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