| pubmed-article:15507314 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15507314 | lifeskim:mentions | umls-concept:C0039005 | lld:lifeskim |
| pubmed-article:15507314 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15507314 | lifeskim:mentions | umls-concept:C1134651 | lld:lifeskim |
| pubmed-article:15507314 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15507314 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15507314 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15507314 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15507314 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:15507314 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:15507314 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15507314 | pubmed:dateCreated | 2004-10-27 | lld:pubmed |
| pubmed-article:15507314 | pubmed:abstractText | Beta-glucan has been shown to enhance anti-tumor and anti-infection functions in animals. Pigs at 4 months of age were infected with porcine reproductive and respiratory syndrome virus (PRRSV), and peripheral blood monocytes (PBMC) were isolated for the detection of interferon gamma (IFNgamma)-producing cells. We found that soluble high molecular weight beta-glucan could increase IFNgamma-producing cell frequency in a dose-dependent manner in the enzyme-linked immunospot assay (ELISPOT) in the absence of antigenic restimulation. A concentration as low as 1.6 microg/ml gave a significant increase and a similarly high enhancement was achieved at concentrations from 3.2 to 100 microg/ml. In PRRSV-specific IFNgamma ELISPOT, soluble beta-glucan elicited increased PRRSV-specific responses at concentrations from 3.2 to 50 microg/ml, but not at 100 microg/ml, whereas insoluble beta-glucan had no effect. Soluble beta-glucan augmented the porcine cellular immune response in an antigen-independent fashion, whereas insoluble beta-glucan had no activity. This finding suggests that soluble beta-glucan may enhance innate antiviral immunity against PRRSV. | lld:pubmed |
| pubmed-article:15507314 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15507314 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15507314 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15507314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15507314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15507314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15507314 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15507314 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15507314 | pubmed:issn | 0165-2427 | lld:pubmed |
| pubmed-article:15507314 | pubmed:author | pubmed-author:MurtaughMicha... | lld:pubmed |
| pubmed-article:15507314 | pubmed:author | pubmed-author:XiaoZhengguoZ | lld:pubmed |
| pubmed-article:15507314 | pubmed:author | pubmed-author:TrincadoCarlo... | lld:pubmed |
| pubmed-article:15507314 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15507314 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:15507314 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:15507314 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15507314 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15507314 | pubmed:pagination | 315-20 | lld:pubmed |
| pubmed-article:15507314 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:15507314 | pubmed:meshHeading | pubmed-meshheading:15507314... | lld:pubmed |
| pubmed-article:15507314 | pubmed:meshHeading | pubmed-meshheading:15507314... | lld:pubmed |
| pubmed-article:15507314 | pubmed:meshHeading | pubmed-meshheading:15507314... | lld:pubmed |
| pubmed-article:15507314 | pubmed:meshHeading | pubmed-meshheading:15507314... | lld:pubmed |
| pubmed-article:15507314 | pubmed:meshHeading | pubmed-meshheading:15507314... | lld:pubmed |
| pubmed-article:15507314 | pubmed:meshHeading | pubmed-meshheading:15507314... | lld:pubmed |
| pubmed-article:15507314 | pubmed:meshHeading | pubmed-meshheading:15507314... | lld:pubmed |
| pubmed-article:15507314 | pubmed:meshHeading | pubmed-meshheading:15507314... | lld:pubmed |
| pubmed-article:15507314 | pubmed:meshHeading | pubmed-meshheading:15507314... | lld:pubmed |
| pubmed-article:15507314 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15507314 | pubmed:articleTitle | Beta-glucan enhancement of T cell IFNgamma response in swine. | lld:pubmed |
| pubmed-article:15507314 | pubmed:affiliation | Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St. Paul, MN 55108, USA. | lld:pubmed |
| pubmed-article:15507314 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15507314 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:15507314 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:15507314 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15507314 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15507314 | lld:pubmed |
