| pubmed-article:15504753 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15504753 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:15504753 | lifeskim:mentions | umls-concept:C1512072 | lld:lifeskim |
| pubmed-article:15504753 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15504753 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:15504753 | lifeskim:mentions | umls-concept:C0452456 | lld:lifeskim |
| pubmed-article:15504753 | lifeskim:mentions | umls-concept:C0452458 | lld:lifeskim |
| pubmed-article:15504753 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:15504753 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:15504753 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:15504753 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15504753 | pubmed:dateCreated | 2004-11-25 | lld:pubmed |
| pubmed-article:15504753 | pubmed:abstractText | We investigated the effects of grapefruit juice (GFJ) and orange juice (OJ) on drug transport by MDR1 P-glycoprotein (P-gp) and multidrug resistance protein 2 (MRP2), which are efflux transporters expressed in human small intestine. We examined the transcellular transport and uptake of [(3)H]vinblastine (VBL) and [(14)C]saquinavir in a human colon carcinoma cell line (Caco-2) and in porcine kidney epithelial cell lines transfected with human MDR1 cDNA and human MRP2 cDNA, LLC-GA5-COL150, and LLC-MRP2, respectively. In Caco-2 cells, the basal-to-apical transports of [(3)H]VBL and [(14)C]saquinavir were greater than those in the opposite direction. The ratio of basal-to-apical transport to apical-to-basal transport of [(3)H]VBL and [(14)C]saquinavir by Caco-2 cells was reduced in the presence of MK571 (MRPs inhibitor), verapamil (P-gp inhibitor), cyclosporin A (inhibitor of both), 50% ethyl acetate extracts of GFJ and OJ, or their components (6',7'-dihydroxybergamottin, bergamottin, tangeretin, hepatomethoxyflavone, and nobiletin). Studies of transport and uptake of [(3)H]VBL and [(14)C]saquinavir with MDR1 and MRP2 transfectants showed that VBL and saquinavir are transported by both P-gp and MRP2. GFJ and OJ components inhibited the transport by MRP2 as well as P-gp. However, their inhibitory potencies for P-gp or MRP2 were substrate-dependent. The present study has revealed that GFJ and OJ interact with not only P-gp but also MRP2, both of which are expressed at apical membranes and limit the apical-to-basal transport of VBL and saquinavir in Caco-2 cells. | lld:pubmed |
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| pubmed-article:15504753 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15504753 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15504753 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15504753 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15504753 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15504753 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:15504753 | pubmed:author | pubmed-author:MorimotoSatos... | lld:pubmed |
| pubmed-article:15504753 | pubmed:author | pubmed-author:OhtaniHisakaz... | lld:pubmed |
| pubmed-article:15504753 | pubmed:author | pubmed-author:KoyabuNorikoN | lld:pubmed |
| pubmed-article:15504753 | pubmed:author | pubmed-author:SawadaYasufum... | lld:pubmed |
| pubmed-article:15504753 | pubmed:author | pubmed-author:UshigomeFumih... | lld:pubmed |
| pubmed-article:15504753 | pubmed:author | pubmed-author:KuwanoMichihi... | lld:pubmed |
| pubmed-article:15504753 | pubmed:author | pubmed-author:UchiumiTakesh... | lld:pubmed |
| pubmed-article:15504753 | pubmed:author | pubmed-author:ShoyamaYukihi... | lld:pubmed |
| pubmed-article:15504753 | pubmed:author | pubmed-author:HondaYokoY | lld:pubmed |
| pubmed-article:15504753 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15504753 | pubmed:volume | 143 | lld:pubmed |
| pubmed-article:15504753 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15504753 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15504753 | pubmed:pagination | 856-64 | lld:pubmed |
| pubmed-article:15504753 | pubmed:dateRevised | 2010-9-21 | lld:pubmed |
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| pubmed-article:15504753 | pubmed:year | 2004 | lld:pubmed |
