| pubmed-article:15501757 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15501757 | lifeskim:mentions | umls-concept:C0206255 | lld:lifeskim |
| pubmed-article:15501757 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15501757 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15501757 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15501757 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15501757 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:15501757 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15501757 | pubmed:dateCreated | 2004-10-25 | lld:pubmed |
| pubmed-article:15501757 | pubmed:abstractText | The 3D7 form of the merozoite surface protein 2 (MSP2) of Plasmodium falciparum was one of three subunits of the malaria vaccine Combination B that were tested in a phase I/IIb double-blind randomized placebo-controlled trial, which was undertaken with 120 Papua New Guinean children of 5 to 9 years of age. Because only one variant of the highly polymorphic MSP2 was used for vaccination, we examined whether the elicited response was directed against conserved or strain-specific epitopes. Postvaccination (week 12) titers of antibody against recombinantly expressed individual domains of MSP2 were measured by enzyme-linked immunosorbent assay and compared to baseline values. We found that vaccination with the 3D7 form of MSP2 induced a significant strain-specific humoral response directed against the repetitive and semiconserved family-specific part. The conserved N- and C-terminal domains were not immunogenic. Titers of antibody against the alternate FC27 family-specific domain showed a tendency to increase in vaccinated children, but there was no increase in antibodies against FC27-type 32-mer repeats. These results indicate that vaccination with one MSP2 variant mainly induced a strain-specific response, which can explain the selective effect of vaccination with combination B on the genotypes of breakthrough parasites. These findings support the inclusion of both family-specific domains (3D7 and FC27) in an improved vaccine formulation. | lld:pubmed |
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| pubmed-article:15501757 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15501757 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15501757 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15501757 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15501757 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15501757 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:15501757 | pubmed:author | pubmed-author:IrionAndreaA | lld:pubmed |
| pubmed-article:15501757 | pubmed:author | pubmed-author:SmithTomT | lld:pubmed |
| pubmed-article:15501757 | pubmed:author | pubmed-author:SaulAllanA | lld:pubmed |
| pubmed-article:15501757 | pubmed:author | pubmed-author:GentonBlaiseB | lld:pubmed |
| pubmed-article:15501757 | pubmed:author | pubmed-author:BeckHans-Pete... | lld:pubmed |
| pubmed-article:15501757 | pubmed:author | pubmed-author:AlpersMichael... | lld:pubmed |
| pubmed-article:15501757 | pubmed:author | pubmed-author:BetuelaInoniI | lld:pubmed |
| pubmed-article:15501757 | pubmed:author | pubmed-author:FelgerIngridI | lld:pubmed |
| pubmed-article:15501757 | pubmed:author | pubmed-author:FlückChristia... | lld:pubmed |
| pubmed-article:15501757 | pubmed:author | pubmed-author:AndersRobinR | lld:pubmed |
| pubmed-article:15501757 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15501757 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:15501757 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15501757 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15501757 | pubmed:pagination | 6300-5 | lld:pubmed |
| pubmed-article:15501757 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15501757 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15501757 | pubmed:articleTitle | Strain-specific humoral response to a polymorphic malaria vaccine. | lld:pubmed |
| pubmed-article:15501757 | pubmed:affiliation | Swiss Tropical Institute, Socinstrasse 57, Basel. | lld:pubmed |
| pubmed-article:15501757 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15501757 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:15501757 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:15501757 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15501757 | pubmed:publicationType | Clinical Trial, Phase II | lld:pubmed |
| pubmed-article:15501757 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
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