| pubmed-article:15501058 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15501058 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15501058 | lifeskim:mentions | umls-concept:C0001006 | lld:lifeskim |
| pubmed-article:15501058 | lifeskim:mentions | umls-concept:C0667282 | lld:lifeskim |
| pubmed-article:15501058 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:15501058 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:15501058 | pubmed:dateCreated | 2004-10-25 | lld:pubmed |
| pubmed-article:15501058 | pubmed:abstractText | We have identified and synthesized a series of 4-thiopyridyl acetophenones as positive allosteric potentiators of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward replacement of the tetrazole in the initial lead led to the discovery of 16 (EC(50)=340 nM), which showed improved brain penetration over the initial lead. | lld:pubmed |
| pubmed-article:15501058 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15501058 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15501058 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15501058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15501058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15501058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15501058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15501058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15501058 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15501058 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15501058 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:15501058 | pubmed:author | pubmed-author:HutchinsonJoh... | lld:pubmed |
| pubmed-article:15501058 | pubmed:author | pubmed-author:GardnerMichae... | lld:pubmed |
| pubmed-article:15501058 | pubmed:author | pubmed-author:PinkertonAnth... | lld:pubmed |
| pubmed-article:15501058 | pubmed:author | pubmed-author:SchaffhauserH... | lld:pubmed |
| pubmed-article:15501058 | pubmed:author | pubmed-author:VernierJean-M... | lld:pubmed |
| pubmed-article:15501058 | pubmed:author | pubmed-author:RoweBlake ABA | lld:pubmed |
| pubmed-article:15501058 | pubmed:author | pubmed-author:DaggettLorrie... | lld:pubmed |
| pubmed-article:15501058 | pubmed:author | pubmed-author:JamesJoyce... | lld:pubmed |
| pubmed-article:15501058 | pubmed:author | pubmed-author:CubeRowena... | lld:pubmed |
| pubmed-article:15501058 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15501058 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:15501058 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:15501058 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15501058 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15501058 | pubmed:pagination | 5867-72 | lld:pubmed |
| pubmed-article:15501058 | pubmed:meshHeading | pubmed-meshheading:15501058... | lld:pubmed |
| pubmed-article:15501058 | pubmed:meshHeading | pubmed-meshheading:15501058... | lld:pubmed |
| pubmed-article:15501058 | pubmed:meshHeading | pubmed-meshheading:15501058... | lld:pubmed |
| pubmed-article:15501058 | pubmed:meshHeading | pubmed-meshheading:15501058... | lld:pubmed |
| pubmed-article:15501058 | pubmed:meshHeading | pubmed-meshheading:15501058... | lld:pubmed |
| pubmed-article:15501058 | pubmed:meshHeading | pubmed-meshheading:15501058... | lld:pubmed |
| pubmed-article:15501058 | pubmed:meshHeading | pubmed-meshheading:15501058... | lld:pubmed |
| pubmed-article:15501058 | pubmed:meshHeading | pubmed-meshheading:15501058... | lld:pubmed |
| pubmed-article:15501058 | pubmed:meshHeading | pubmed-meshheading:15501058... | lld:pubmed |
| pubmed-article:15501058 | pubmed:meshHeading | pubmed-meshheading:15501058... | lld:pubmed |
| pubmed-article:15501058 | pubmed:meshHeading | pubmed-meshheading:15501058... | lld:pubmed |
| pubmed-article:15501058 | pubmed:meshHeading | pubmed-meshheading:15501058... | lld:pubmed |
| pubmed-article:15501058 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15501058 | pubmed:articleTitle | Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators. | lld:pubmed |
| pubmed-article:15501058 | pubmed:affiliation | Merck Research Laboratories, MRLSDB2, 3535 General Atomics Court, San Diego, CA 92121, USA. anthony_pinkerton@merck.com | lld:pubmed |
| pubmed-article:15501058 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:15501058 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15501058 | lld:pubmed |
