| pubmed-article:15494521 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15494521 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:15494521 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15494521 | lifeskim:mentions | umls-concept:C1335872 | lld:lifeskim |
| pubmed-article:15494521 | lifeskim:mentions | umls-concept:C1367307 | lld:lifeskim |
| pubmed-article:15494521 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
| pubmed-article:15494521 | lifeskim:mentions | umls-concept:C1419227 | lld:lifeskim |
| pubmed-article:15494521 | lifeskim:mentions | umls-concept:C0205289 | lld:lifeskim |
| pubmed-article:15494521 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15494521 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:15494521 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15494521 | pubmed:dateCreated | 2004-10-20 | lld:pubmed |
| pubmed-article:15494521 | pubmed:abstractText | Rac1 GTPase is implicated as a signaling mediator in various cellular events. In this study, we show that Rac1 contributes to IFN-gamma-induced inflammatory responses in rat astrocytes. We revealed that IFN-gamma rapidly stimulated activation of Rac1 in C6 astroglioma cells by investigating GST-PAK-PBD-binding ability. We also found that Rac1 deficiency led to attenuation of IFN-gamma-responsive transcriptional responses. Compared with levels in control cells, IFN-gamma-induced IFN-gamma-activated sequence promoter activity was markedly reduced in both C6 astroglioma cells and primary astrocytes expressing RacN17, a well-characterized Rac1-negative mutant. The expression of several IFN-gamma-responsive genes, such as MCP-1 and ICAM-1, was also reduced in cells expressing RacN17. Consistent with these observations, IFN-gamma-induced phosphorylation of STAT1 and STAT3 was lower in C6 cells expressing RacN17 (referred to as C6-RacN17) than in control cells. However, there was no difference in expression level of IFN-gammaRalpha subunit and IFN-gamma-induced phosphorylation of JAK1 between C6 control and C6-RacN17 cells. Interestingly, Rac1 appeared to associate with IFN-gammaRalpha and augment the interaction of IFN-gammaR with either STAT1 or STAT3 in response to IFN-gamma. Taken together, we suggest that Rac1 may serve as an auxiliary mediator of IFN-gamma-signaling, at least at the level of STAT activation, thus contributing to maximal activation of IFN-gamma-responsive inflammatory signaling in rat astrocytes. | lld:pubmed |
| pubmed-article:15494521 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15494521 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494521 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15494521 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15494521 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15494521 | pubmed:author | pubmed-author:KimJae-HongJH | lld:pubmed |
| pubmed-article:15494521 | pubmed:author | pubmed-author:YouHye-JinHJ | lld:pubmed |
| pubmed-article:15494521 | pubmed:author | pubmed-author:ParkEun... | lld:pubmed |
| pubmed-article:15494521 | pubmed:author | pubmed-author:JouIloI | lld:pubmed |
| pubmed-article:15494521 | pubmed:author | pubmed-author:JoeEun-HyeEH | lld:pubmed |
| pubmed-article:15494521 | pubmed:author | pubmed-author:HanInn-OcIO | lld:pubmed |
| pubmed-article:15494521 | pubmed:author | pubmed-author:JiKyung-AeKA | lld:pubmed |
| pubmed-article:15494521 | pubmed:author | pubmed-author:JeonSae-BomSB | lld:pubmed |
| pubmed-article:15494521 | pubmed:author | pubmed-author:ChoiWoo-Hyuck... | lld:pubmed |
| pubmed-article:15494521 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15494521 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15494521 | pubmed:volume | 173 | lld:pubmed |
| pubmed-article:15494521 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15494521 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15494521 | pubmed:pagination | 5697-703 | lld:pubmed |
| pubmed-article:15494521 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:meshHeading | pubmed-meshheading:15494521... | lld:pubmed |
| pubmed-article:15494521 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15494521 | pubmed:articleTitle | Rac1 contributes to maximal activation of STAT1 and STAT3 in IFN-gamma-stimulated rat astrocytes. | lld:pubmed |
| pubmed-article:15494521 | pubmed:affiliation | Department of Pharmacology, School of Medicine, Ajou University, Suwon, Korea. | lld:pubmed |
| pubmed-article:15494521 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15494521 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15494521 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:5879 | entrezgene:pubmed | pubmed-article:15494521 | lld:entrezgene |
| entrez-gene:6772 | entrezgene:pubmed | pubmed-article:15494521 | lld:entrezgene |
| entrez-gene:3459 | entrezgene:pubmed | pubmed-article:15494521 | lld:entrezgene |
| entrez-gene:363875 | entrezgene:pubmed | pubmed-article:15494521 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15494521 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15494521 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15494521 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15494521 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15494521 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15494521 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15494521 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15494521 | lld:pubmed |
