| pubmed-article:15494372 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15494372 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:15494372 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:15494372 | lifeskim:mentions | umls-concept:C1512032 | lld:lifeskim |
| pubmed-article:15494372 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15494372 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:15494372 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:15494372 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:15494372 | pubmed:issue | Pt 23 | lld:pubmed |
| pubmed-article:15494372 | pubmed:dateCreated | 2004-10-28 | lld:pubmed |
| pubmed-article:15494372 | pubmed:abstractText | Currently, there is no treatment to cure transmissible spongiform encephalopathies. By taking advantage of the 'prion-resistant' polymorphisms Q171R and E219K that naturally exist in sheep and humans, respectively, we have evaluated a therapeutic approach of lentiviral gene transfer. Here, we show that VSV-G (vesicular stomatitis virus G glycoprotein) pseudotyped FIV-(feline immunodeficiency virus) derived vectors carrying the mouse Prnp gene in which these mutations have been inserted, are able to inhibit prion replication in chronically prion-infected cells. Because lentiviral tools are able to transduce post-mitotic cells such as neurons or cells of the lymphoreticular system, this result might help the development of gene- or cell-therapy approaches to prion disease. | lld:pubmed |
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| pubmed-article:15494372 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15494372 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494372 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15494372 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15494372 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15494372 | pubmed:issn | 0021-9533 | lld:pubmed |
| pubmed-article:15494372 | pubmed:author | pubmed-author:LehmannSylvai... | lld:pubmed |
| pubmed-article:15494372 | pubmed:author | pubmed-author:PerrierVéroni... | lld:pubmed |
| pubmed-article:15494372 | pubmed:author | pubmed-author:CorbeauPierre... | lld:pubmed |
| pubmed-article:15494372 | pubmed:author | pubmed-author:CrozetCaroleC | lld:pubmed |
| pubmed-article:15494372 | pubmed:author | pubmed-author:LinYea-LihYL | lld:pubmed |
| pubmed-article:15494372 | pubmed:author | pubmed-author:MettlingCléme... | lld:pubmed |
| pubmed-article:15494372 | pubmed:author | pubmed-author:Mourton-Gille... | lld:pubmed |
| pubmed-article:15494372 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15494372 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15494372 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:15494372 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15494372 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15494372 | pubmed:pagination | 5591-7 | lld:pubmed |
| pubmed-article:15494372 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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