| pubmed-article:15494304 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15494304 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:15494304 | lifeskim:mentions | umls-concept:C0041917 | lld:lifeskim |
| pubmed-article:15494304 | lifeskim:mentions | umls-concept:C0728940 | lld:lifeskim |
| pubmed-article:15494304 | lifeskim:mentions | umls-concept:C0544886 | lld:lifeskim |
| pubmed-article:15494304 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:15494304 | lifeskim:mentions | umls-concept:C1705483 | lld:lifeskim |
| pubmed-article:15494304 | lifeskim:mentions | umls-concept:C1999230 | lld:lifeskim |
| pubmed-article:15494304 | lifeskim:mentions | umls-concept:C1881865 | lld:lifeskim |
| pubmed-article:15494304 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15494304 | pubmed:dateCreated | 2004-10-20 | lld:pubmed |
| pubmed-article:15494304 | pubmed:abstractText | AID-mediated deamination of dC residues within the immunoglobulin locus generates dU:dG lesions whose resolution leads to class-switch recombination and somatic hypermutation. The dU:dG pair is a mismatch and comprises a base foreign to DNA and is, thus, recognized by proteins from both base excision (uracil-DNA glycosylase, UNG) and mismatch recognition (MSH2/MSH6) pathways. Strikingly, while antibody diversification is perturbed by single deficiency in either UNG or MSH2, combined UNG/MSH2 deficiency leads to a total ablation both of switch recombination and of IgV hypermutation at dA:dT pairs. The initiating dU:dG lesions appear not to be recognized and are simply replicated over. The results indicate that the major pathway for switch recombination occurs through uracil excision with mismatch recognition of dU:dG providing a backup; the second phase of hypermutation (essentially introducing mutations solely at dA:dT pairs) is triggered by mismatch recognition of the dU:dG lesion with uracil excision providing a backup. | lld:pubmed |
| pubmed-article:15494304 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15494304 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15494304 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15494304 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15494304 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15494304 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:15494304 | pubmed:author | pubmed-author:NeubergerMich... | lld:pubmed |
| pubmed-article:15494304 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:15494304 | pubmed:author | pubmed-author:RadaCristinaC | lld:pubmed |
| pubmed-article:15494304 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15494304 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:15494304 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:15494304 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15494304 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15494304 | pubmed:pagination | 163-71 | lld:pubmed |
| pubmed-article:15494304 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15494304 | pubmed:meshHeading | pubmed-meshheading:15494304... | lld:pubmed |
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| pubmed-article:15494304 | pubmed:meshHeading | pubmed-meshheading:15494304... | lld:pubmed |
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| pubmed-article:15494304 | pubmed:meshHeading | pubmed-meshheading:15494304... | lld:pubmed |
| pubmed-article:15494304 | pubmed:meshHeading | pubmed-meshheading:15494304... | lld:pubmed |
| pubmed-article:15494304 | pubmed:meshHeading | pubmed-meshheading:15494304... | lld:pubmed |
| pubmed-article:15494304 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15494304 | pubmed:articleTitle | Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. | lld:pubmed |
| pubmed-article:15494304 | pubmed:affiliation | Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom. car@mrc-lmb.cam.ac.uk | lld:pubmed |
| pubmed-article:15494304 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15494304 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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