| pubmed-article:15493259 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15493259 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15493259 | lifeskim:mentions | umls-concept:C0021759 | lld:lifeskim |
| pubmed-article:15493259 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:15493259 | lifeskim:mentions | umls-concept:C0206071 | lld:lifeskim |
| pubmed-article:15493259 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:15493259 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:15493259 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15493259 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15493259 | pubmed:dateCreated | 2004-10-20 | lld:pubmed |
| pubmed-article:15493259 | pubmed:abstractText | There is a body of evidence suggesting that IgA production is regulated by helper T cells or their products. To elucidate molecular mechanisms of IgA production, the role of lymphokines in the in vitro antigen-specific and polyclonal IgA responses was examined. Supernatants from antigen-stimulated T cells or mitogen-stimulated T-cell clones can enhance 2,4-dinitro phenyl (DNP)-specific IgM, IgG1 and IgA production in cultures of DNP-ovalbumin (OVA)-stimulated T-cell-depleted spleen cells from DNP-keyhole limpet haemocyanin-primed mice. The IgA enhancement was inhibited by anti-IL-5 monoclonal antibody. Purified recombinant IL-5 could also enhance anti-DNP IgA production in a dose-dependent manner. This enhancing effect was not substituted by IL-1, IL-2, IL-3 or IL-4. Polyclonal IgA secretion of lipopolysaccharide-stimulated normal B cells was augmented preferentially by IL-5, but not by IL-4. Surface IgA-positive (sIgA+) B cells, but not surface IgA-negative B cells, responded to IL-5 for the development of IgA-secreting cells. Limiting-dilution analysis revealed that IL-5 increases the frequency of IgA-secreting cells in sIgA+ B-cell populations. These results indicate that IL-5 plays an essential role in the antigen-specific and polyclonal IgA formation as a maturation-inducing factor rather than class-switching factor. | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15493259 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15493259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15493259 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15493259 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15493259 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:15493259 | pubmed:author | pubmed-author:MatsumotoMM | lld:pubmed |
| pubmed-article:15493259 | pubmed:author | pubmed-author:AndoMM | lld:pubmed |
| pubmed-article:15493259 | pubmed:author | pubmed-author:YamaguchiNN | lld:pubmed |
| pubmed-article:15493259 | pubmed:author | pubmed-author:TakatsuKK | lld:pubmed |
| pubmed-article:15493259 | pubmed:author | pubmed-author:ArakiSS | lld:pubmed |
| pubmed-article:15493259 | pubmed:author | pubmed-author:MatsumotoRR | lld:pubmed |
| pubmed-article:15493259 | pubmed:author | pubmed-author:TominagaAA | lld:pubmed |
| pubmed-article:15493259 | pubmed:author | pubmed-author:MitaSS | lld:pubmed |
| pubmed-article:15493259 | pubmed:author | pubmed-author:HitoshiYY | lld:pubmed |
| pubmed-article:15493259 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15493259 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:15493259 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15493259 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15493259 | pubmed:pagination | 32-8 | lld:pubmed |
| pubmed-article:15493259 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15493259 | pubmed:meshHeading | pubmed-meshheading:15493259... | lld:pubmed |
| pubmed-article:15493259 | pubmed:meshHeading | pubmed-meshheading:15493259... | lld:pubmed |
| pubmed-article:15493259 | pubmed:meshHeading | pubmed-meshheading:15493259... | lld:pubmed |
| pubmed-article:15493259 | pubmed:meshHeading | pubmed-meshheading:15493259... | lld:pubmed |
| pubmed-article:15493259 | pubmed:meshHeading | pubmed-meshheading:15493259... | lld:pubmed |
| pubmed-article:15493259 | pubmed:meshHeading | pubmed-meshheading:15493259... | lld:pubmed |
| pubmed-article:15493259 | pubmed:meshHeading | pubmed-meshheading:15493259... | lld:pubmed |
| pubmed-article:15493259 | pubmed:meshHeading | pubmed-meshheading:15493259... | lld:pubmed |
| pubmed-article:15493259 | pubmed:meshHeading | pubmed-meshheading:15493259... | lld:pubmed |
| pubmed-article:15493259 | pubmed:meshHeading | pubmed-meshheading:15493259... | lld:pubmed |
| pubmed-article:15493259 | pubmed:meshHeading | pubmed-meshheading:15493259... | lld:pubmed |
| pubmed-article:15493259 | pubmed:meshHeading | pubmed-meshheading:15493259... | lld:pubmed |
| pubmed-article:15493259 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:15493259 | pubmed:articleTitle | Interleukin-5 induces maturation but not class switching of surface IgA-positive B cells into IgA-secreting cells. | lld:pubmed |
| pubmed-article:15493259 | pubmed:affiliation | Department of Biology, Institute for Medical Immunology, Honjo, Kumamoto, Japan. | lld:pubmed |
| pubmed-article:15493259 | pubmed:publicationType | Journal Article | lld:pubmed |
