| pubmed-article:15492122 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15492122 | lifeskim:mentions | umls-concept:C0032112 | lld:lifeskim |
| pubmed-article:15492122 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15492122 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:15492122 | lifeskim:mentions | umls-concept:C1516356 | lld:lifeskim |
| pubmed-article:15492122 | lifeskim:mentions | umls-concept:C0392762 | lld:lifeskim |
| pubmed-article:15492122 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:15492122 | lifeskim:mentions | umls-concept:C1704788 | lld:lifeskim |
| pubmed-article:15492122 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15492122 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15492122 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15492122 | pubmed:dateCreated | 2004-10-19 | lld:pubmed |
| pubmed-article:15492122 | pubmed:abstractText | Plasma cells comprise a population of terminally differentiated B cells that are dependent on the transcriptional regulator B lymphocyte--induced maturation protein 1 (Blimp-1) for their development. We have introduced a gfp reporter into the Blimp-1 locus and shown that heterozygous mice express the green fluorescent protein in all antibody-secreting cells (ASCs) in vivo and in vitro. In vitro, these cells display considerable heterogeneity in surface phenotype, immunoglobulin secretion rate, and Blimp-1 expression levels. Importantly, analysis of in vivo ASCs induced by immunization reveals a developmental pathway in which increasing levels of Blimp-1 expression define developmental stages of plasma cell differentiation that have many phenotypic and molecular correlates. Thus, maturation from transient plasmablast to long-lived ASCs in bone marrow is predicated on quantitative increases in Blimp-1 expression. | lld:pubmed |
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| pubmed-article:15492122 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15492122 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15492122 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15492122 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15492122 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:15492122 | pubmed:author | pubmed-author:NuttStephen... | lld:pubmed |
| pubmed-article:15492122 | pubmed:author | pubmed-author:KalliesAxelA | lld:pubmed |
| pubmed-article:15492122 | pubmed:author | pubmed-author:HasboldJhagva... | lld:pubmed |
| pubmed-article:15492122 | pubmed:author | pubmed-author:HodgkinPhilip... | lld:pubmed |
| pubmed-article:15492122 | pubmed:author | pubmed-author:TarlintonDavi... | lld:pubmed |
| pubmed-article:15492122 | pubmed:author | pubmed-author:DietrichWendy... | lld:pubmed |
| pubmed-article:15492122 | pubmed:author | pubmed-author:CorcoranLynn... | lld:pubmed |
| pubmed-article:15492122 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15492122 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:15492122 | pubmed:volume | 200 | lld:pubmed |
| pubmed-article:15492122 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15492122 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15492122 | pubmed:pagination | 967-77 | lld:pubmed |
| pubmed-article:15492122 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15492122 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15492122 | pubmed:articleTitle | Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. | lld:pubmed |
| pubmed-article:15492122 | pubmed:affiliation | The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3050, Australia. | lld:pubmed |
| pubmed-article:15492122 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15492122 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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