| pubmed-article:15479735 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15479735 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15479735 | lifeskim:mentions | umls-concept:C0085182 | lld:lifeskim |
| pubmed-article:15479735 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:15479735 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15479735 | pubmed:dateCreated | 2004-10-13 | lld:pubmed |
| pubmed-article:15479735 | pubmed:abstractText | Talin, an adaptor between integrin and the actin cytoskeleton at sites of cell adhesion, was recently found to be present at neuronal synapses, where its function remains unknown. Talin interacts with phosphatidylinositol-(4)-phosphate 5-kinase type Igamma, the major phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)]-synthesizing enzyme in brain. To gain insight into the synaptic role of talin, we microinjected into the large lamprey axons reagents that compete the talin-PIP kinase interaction and then examined their effects on synaptic structure. A dramatic decrease of synaptic actin and an impairment of clathrin-mediated synaptic vesicle endocytosis were observed. The endocytic defect included an accumulation of clathrin-coated pits with wide necks, as previously observed after perturbing actin at these synapses. Thus, the interaction of PIP kinase with talin in presynaptic compartments provides a mechanism to coordinate PI(4,5)P(2) synthesis, actin dynamics, and endocytosis, and further supports a functional link between actin and clathrin-mediated endocytosis. | lld:pubmed |
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| pubmed-article:15479735 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15479735 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15479735 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15479735 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15479735 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:15479735 | pubmed:author | pubmed-author:PieriboneVinc... | lld:pubmed |
| pubmed-article:15479735 | pubmed:author | pubmed-author:PypaertMarcM | lld:pubmed |
| pubmed-article:15479735 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:15479735 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:15479735 | pubmed:author | pubmed-author:MorganJennife... | lld:pubmed |
| pubmed-article:15479735 | pubmed:author | pubmed-author:WernerHaukeH | lld:pubmed |
| pubmed-article:15479735 | pubmed:author | pubmed-author:ShchedrinaVal... | lld:pubmed |
| pubmed-article:15479735 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15479735 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:15479735 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:15479735 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15479735 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15479735 | pubmed:pagination | 43-50 | lld:pubmed |
| pubmed-article:15479735 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15479735 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15479735 | pubmed:articleTitle | A role for talin in presynaptic function. | lld:pubmed |
| pubmed-article:15479735 | pubmed:affiliation | Department of Cell Biology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06519, USA. | lld:pubmed |
| pubmed-article:15479735 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15479735 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
