| pubmed-article:1547825 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1547825 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:1547825 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1547825 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:1547825 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:1547825 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:1547825 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:1547825 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1547825 | pubmed:dateCreated | 1992-4-21 | lld:pubmed |
| pubmed-article:1547825 | pubmed:abstractText | We investigated peripheral blood B and T lymphocyte functions in atopic individuals. B cells were co-cultured with mutant EL4 thymoma cells in the presence of a standard T cell supernatant (T-SN) with or without exogenous interleukin (IL)-4. IgE secretion in this assay was found to be IL-4 dependent, but not significantly different for atopic patients (n = 25) vs. normal controls (n = 25). Phytohemagglutinin plus phorbol 12-myristate 13-acetate (PHA+PMA)- induced T-SN from patients or controls was tested on normal B cells in the same assay system (in the absence of exogenous IL-4). Compared to the controls, the IgE-inducing activity was significantly increased for patients with asthma or allergic rhinitis (n = 12; p less than 0.005) but not for patients with atopic dermatitis (n = 13). The difference between the asthma or allergic rhinitis vs. the atopic dermatitis groups was significant (p greater than 0.05). Since the assay was not inhibited by interferon (IFN)-gamma, this difference can not be attributed to IFN-gamma concentrations. Other T cell activities may be different between the patient groups or atopic T cells from the respiratory mucosa may recirculate more than those from the skin. In any case, the T cells rather than the B cells were found to be abnormal in atopic individuals. If atopic T cells were stimulated with PHA+PMA not as immediately but after a resting period of 48 h in culture medium alone, the IgE-inducing activity, but not the total Ig-inducing activity or the IL-2 secretion, disappeared. In addition, a mean of 37% of the IgE-inducing activity (range of 13% to 79% for five very active T-SN) was not inhibited by an anti-IL-4 antibody which neutralized exogenous IL-4, indicating a participation of factors capable of bypassing the requirement for IL-4 for the IgE response. | lld:pubmed |
| pubmed-article:1547825 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1547825 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1547825 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1547825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1547825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1547825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1547825 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1547825 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1547825 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:1547825 | pubmed:author | pubmed-author:ZublerR HRH | lld:pubmed |
| pubmed-article:1547825 | pubmed:author | pubmed-author:HausenGG | lld:pubmed |
| pubmed-article:1547825 | pubmed:author | pubmed-author:ZhangXX | lld:pubmed |
| pubmed-article:1547825 | pubmed:author | pubmed-author:PolliJJ | lld:pubmed |
| pubmed-article:1547825 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1547825 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:1547825 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1547825 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1547825 | pubmed:pagination | 829-33 | lld:pubmed |
| pubmed-article:1547825 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1547825 | pubmed:meshHeading | pubmed-meshheading:1547825-... | lld:pubmed |
| pubmed-article:1547825 | pubmed:meshHeading | pubmed-meshheading:1547825-... | lld:pubmed |
| pubmed-article:1547825 | pubmed:meshHeading | pubmed-meshheading:1547825-... | lld:pubmed |
| pubmed-article:1547825 | pubmed:meshHeading | pubmed-meshheading:1547825-... | lld:pubmed |
| pubmed-article:1547825 | pubmed:meshHeading | pubmed-meshheading:1547825-... | lld:pubmed |
| pubmed-article:1547825 | pubmed:meshHeading | pubmed-meshheading:1547825-... | lld:pubmed |
| pubmed-article:1547825 | pubmed:meshHeading | pubmed-meshheading:1547825-... | lld:pubmed |
| pubmed-article:1547825 | pubmed:meshHeading | pubmed-meshheading:1547825-... | lld:pubmed |
| pubmed-article:1547825 | pubmed:meshHeading | pubmed-meshheading:1547825-... | lld:pubmed |
| pubmed-article:1547825 | pubmed:meshHeading | pubmed-meshheading:1547825-... | lld:pubmed |
| pubmed-article:1547825 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1547825 | pubmed:articleTitle | T cells from atopic individuals produce IgE-inducing activity incompletely blocked by anti-interleukin-4 antibody. | lld:pubmed |
| pubmed-article:1547825 | pubmed:affiliation | Department of Medicine, Hôpital Cantonal Universitaire, Genève, Switzerland. | lld:pubmed |
| pubmed-article:1547825 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1547825 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1547825 | lld:pubmed |
