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pubmed-article:15477044pubmed:abstractTextLymphocytic cholangitis (LC) in cats is a biliary disease of unknown etiology. Helicobacter spp. were recently implicated in human primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Because of the similarities between PSC/PBC with LC, we hypothesized that Helicobacter spp. are involved in feline LC. A PCR with Helicobacter genus-specific 16S rRNA primers was performed on DNA isolated from feline bile samples. Four of the 15 (26%) LC samples were positive, whereas only 8/51 (16%) of non-LC samples were PCR positive (p=0.44). Sequence analysis of the amplicons revealed a 100% identity with the Helicobacter pylori specific DNA fragments. Our data suggest an etiological role of H. pylori in feline LC and that cats are a potential zoonotic reservoir.lld:pubmed
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pubmed-article:15477044pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15477044pubmed:articleTitleDetection of Helicobacter pylori in bile of cats.lld:pubmed
pubmed-article:15477044pubmed:affiliationDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, P.O. Box 80154, 3508 TD Utrecht, The Netherlands. s.y.boomkens@vet.uu.nllld:pubmed
pubmed-article:15477044pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15477044pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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