| pubmed-article:15467723 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15467723 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:15467723 | lifeskim:mentions | umls-concept:C1413243 | lld:lifeskim |
| pubmed-article:15467723 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:15467723 | lifeskim:mentions | umls-concept:C1366561 | lld:lifeskim |
| pubmed-article:15467723 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:15467723 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15467723 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15467723 | pubmed:dateCreated | 2004-10-21 | lld:pubmed |
| pubmed-article:15467723 | pubmed:abstractText | Bidirectional signaling along the B7-CTLA-4 coreceptor pathway enables reciprocal conditioning of T cells and dendritic cells. Although T cells can instruct dendritic cells to manifest tolerogenic properties after CTLA-4 engagement of B7, such a B7-mediated signaling is not known to occur in response to CD28. Here we show that mouse dendritic cells were induced by soluble CD28 to express interleukin 6 and interferon-gamma. Production of interleukin 6 required B7-1 (CD80), B7-2 (CD86) and p38 mitogen-activated protein kinase and prevented interferon-gamma-driven expression of immunosuppressive tryptophan catabolism. In vivo, an adjuvant activity of soluble CD28 was demonstrated as enhanced T cell-mediated immunity to tumor and self peptides and protection against microbial and tumor challenge. Thus, different ligands of B7 can signal dendritic cells to express functionally distinct effector responses. | lld:pubmed |
| pubmed-article:15467723 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15467723 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15467723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15467723 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15467723 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15467723 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:15467723 | pubmed:author | pubmed-author:FallarinoFran... | lld:pubmed |
| pubmed-article:15467723 | pubmed:author | pubmed-author:VaccaCarmineC | lld:pubmed |
| pubmed-article:15467723 | pubmed:author | pubmed-author:OrabonaCirian... | lld:pubmed |
| pubmed-article:15467723 | pubmed:author | pubmed-author:BianchiRobert... | lld:pubmed |
| pubmed-article:15467723 | pubmed:author | pubmed-author:GrohmannUrsul... | lld:pubmed |
| pubmed-article:15467723 | pubmed:author | pubmed-author:PuccettiPaolo... | lld:pubmed |
| pubmed-article:15467723 | pubmed:author | pubmed-author:BozzaSilviaS | lld:pubmed |
| pubmed-article:15467723 | pubmed:author | pubmed-author:RomaniLuigina... | lld:pubmed |
| pubmed-article:15467723 | pubmed:author | pubmed-author:BelladonnaMar... | lld:pubmed |
| pubmed-article:15467723 | pubmed:author | pubmed-author:FiorettiMaria... | lld:pubmed |
| pubmed-article:15467723 | pubmed:author | pubmed-author:SalomonBenoît... | lld:pubmed |
| pubmed-article:15467723 | pubmed:author | pubmed-author:VolpiClaudiaC | lld:pubmed |
| pubmed-article:15467723 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15467723 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:15467723 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15467723 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15467723 | pubmed:pagination | 1134-42 | lld:pubmed |
| pubmed-article:15467723 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:meshHeading | pubmed-meshheading:15467723... | lld:pubmed |
| pubmed-article:15467723 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15467723 | pubmed:articleTitle | CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86. | lld:pubmed |
| pubmed-article:15467723 | pubmed:affiliation | Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy. | lld:pubmed |
| pubmed-article:15467723 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15467723 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15467723 | lld:pubmed |
