| pubmed-article:15466394 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15466394 | lifeskim:mentions | umls-concept:C1519606 | lld:lifeskim |
| pubmed-article:15466394 | lifeskim:mentions | umls-concept:C1850496 | lld:lifeskim |
| pubmed-article:15466394 | lifeskim:mentions | umls-concept:C1413038 | lld:lifeskim |
| pubmed-article:15466394 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:15466394 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:15466394 | lifeskim:mentions | umls-concept:C0522501 | lld:lifeskim |
| pubmed-article:15466394 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15466394 | pubmed:dateCreated | 2004-10-6 | lld:pubmed |
| pubmed-article:15466394 | pubmed:abstractText | Alzheimer's disease (AD) is characterized by a substantial degeneration of pyramidal neurons and the appearance of neuritic plaques and neurofibrillary tangles. Here we present a novel transgenic mouse model, APP(SL)PS1KI that closely mimics the development of AD-related neuropathological features including a significant hippocampal neuronal loss. This transgenic mouse model carries M233T/L235P knocked-in mutations in presenilin-1 and overexpresses mutated human beta-amyloid (Abeta) precursor protein. Abeta(x-42) is the major form of Abeta species present in this model with progressive development of a complex pattern of N-truncated variants and dimers, similar to those observed in AD brain. At 10 months of age, an extensive neuronal loss (>50%) is present in the CA1/2 hippocampal pyramidal cell layer that correlates with strong accumulation of intraneuronal Abeta and thioflavine-S-positive intracellular material but not with extracellular Abeta deposits. A strong reactive astrogliosis develops together with the neuronal loss. This loss is already detectable at 6 months of age and is PS1KI gene dosage-dependent. Thus, APP(SL)PS1KI mice further confirm the critical role of intraneuronal Abeta(42) in neuronal loss and provide an excellent tool to investigate therapeutic strategies designed to prevent AD neurodegeneration. | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15466394 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15466394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15466394 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15466394 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15466394 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:DelacourteAnd... | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:ClarkAllanA | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:PradierLauren... | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:BlanchardVéro... | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:SchmitzChrist... | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:BayerThomas... | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:SergeantNicol... | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:DrobecqHervéH | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:WirthsOliverO | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:TrempGünterG | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:CasasCatyC | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:ItierJean-Mic... | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:BoniciBrunoB | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:CantonThierry... | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:BenavidesJesú... | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:VingtdeuxValé... | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:van de... | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:RetGwenaëlleG | lld:pubmed |
| pubmed-article:15466394 | pubmed:author | pubmed-author:BenoitPatrick... | lld:pubmed |
| pubmed-article:15466394 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15466394 | pubmed:volume | 165 | lld:pubmed |
| pubmed-article:15466394 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15466394 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15466394 | pubmed:pagination | 1289-300 | lld:pubmed |
| pubmed-article:15466394 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15466394 | pubmed:meshHeading | pubmed-meshheading:15466394... | lld:pubmed |
| pubmed-article:15466394 | pubmed:meshHeading | pubmed-meshheading:15466394... | lld:pubmed |
| pubmed-article:15466394 | pubmed:meshHeading | pubmed-meshheading:15466394... | lld:pubmed |
| pubmed-article:15466394 | pubmed:meshHeading | pubmed-meshheading:15466394... | lld:pubmed |
| pubmed-article:15466394 | pubmed:meshHeading | pubmed-meshheading:15466394... | lld:pubmed |
