In this paper, we examine how skin structure affects the ability of solvents to irritate and permeate the skin; the patterns of cutaneous injury caused by solvents; the effects of specific solvents on the skin; and the potential for systemic toxicity from dermal absorption.
University of Pennsylvania Health System, Silverstein Pavilion, Ground Floor, 3400 Spruce Street, 4 Philadelphia, PA 19104-4238, USA. debra.rowse@uphs.upenn.edu
