| pubmed-article:15465291 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:15465291 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:15465291 | lifeskim:mentions | umls-concept:C0000768 | lld:lifeskim |
| pubmed-article:15465291 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:15465291 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:15465291 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:15465291 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:15465291 | lifeskim:mentions | umls-concept:C0031705 | lld:lifeskim |
| pubmed-article:15465291 | lifeskim:mentions | umls-concept:C0588202 | lld:lifeskim |
| pubmed-article:15465291 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:15465291 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:15465291 | lifeskim:mentions | umls-concept:C2700066 | lld:lifeskim |
| pubmed-article:15465291 | lifeskim:mentions | umls-concept:C0332162 | lld:lifeskim |
| pubmed-article:15465291 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15465291 | pubmed:dateCreated | 2004-10-6 | lld:pubmed |
| pubmed-article:15465291 | pubmed:abstractText | Cerebral bioenergetic and phospholipid abnormalities have been reported in heroin-dependent subjects. The goal of the present study was to characterize the neurochemical profile of subjects voluntarily enrolled in a methadone maintenance (MM) treatment program to overcome their heroin addiction. Participants included 43 heroin-dependent subjects during their first month of MM and 15 age-matched healthy individuals. Phosphorus magnetic resonance spectroscopy ((31)P MRS) and transverse relaxation times (T2-RT), which can reflect steady state cerebral perfusion and metabolism, were acquired at 1.5 T from an axial slice prescribed through the orbitofrontal and occipital cortices, including basal ganglia and frontal cortex. MM subjects exhibited reduced phosphocreatine (PCr) levels (-15.3%), elevated phosphodiesters (+ 12.9%, PDE) and significantly longer T2-RT ((+) 2.1%) compared with healthy comparison subjects. When MM subjects were stratified into subgroups based on treatment duration, we found a treatment duration effect on metabolite values but not T2-RT; reduced PCr was observed only after 8+ days of MM, and phosphomonoesters (PME) were elevated in the 15-28 day MM group. Taken together, these cross-sectional data suggest that the first month of MM treatment may be associated with altered cerebral bioenergetics and phospholipid metabolite levels. | lld:pubmed |
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| pubmed-article:15465291 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15465291 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15465291 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15465291 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15465291 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15465291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15465291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15465291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15465291 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15465291 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15465291 | pubmed:issn | 0165-1781 | lld:pubmed |
| pubmed-article:15465291 | pubmed:author | pubmed-author:MendelsonJack... | lld:pubmed |
| pubmed-article:15465291 | pubmed:author | pubmed-author:RenshawPerry... | lld:pubmed |
| pubmed-article:15465291 | pubmed:author | pubmed-author:PollackMark... | lld:pubmed |
| pubmed-article:15465291 | pubmed:author | pubmed-author:Yurgelun-Todd... | lld:pubmed |
| pubmed-article:15465291 | pubmed:author | pubmed-author:KaufmanMarc... | lld:pubmed |
| pubmed-article:15465291 | pubmed:author | pubmed-author:SilveriMarisa... | lld:pubmed |
| pubmed-article:15465291 | pubmed:author | pubmed-author:NassarLeanne... | lld:pubmed |
| pubmed-article:15465291 | pubmed:author | pubmed-author:DiazClaudia... | lld:pubmed |
| pubmed-article:15465291 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15465291 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15465291 | pubmed:volume | 131 | lld:pubmed |
| pubmed-article:15465291 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15465291 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15465291 | pubmed:pagination | 217-26 | lld:pubmed |
| pubmed-article:15465291 | pubmed:dateRevised | 2008-4-17 | lld:pubmed |
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| pubmed-article:15465291 | pubmed:meshHeading | pubmed-meshheading:15465291... | lld:pubmed |
| pubmed-article:15465291 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15465291 | pubmed:articleTitle | Cerebral phosphorus metabolite and transverse relaxation time abnormalities in heroin-dependent subjects at onset of methadone maintenance treatment. | lld:pubmed |
| pubmed-article:15465291 | pubmed:affiliation | Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. | lld:pubmed |
| pubmed-article:15465291 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15465291 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15465291 | lld:pubmed |
