| pubmed-article:1541677 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C0344315 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C0741968 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:1541677 | lifeskim:mentions | umls-concept:C0449379 | lld:lifeskim |
| pubmed-article:1541677 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1541677 | pubmed:dateCreated | 1992-4-7 | lld:pubmed |
| pubmed-article:1541677 | pubmed:abstractText | Inflammatory mediators released by macrophages (M phi) are believed to be involved in septic vasoplegia. To investigate the effect of M phi on vascular reactivity, excised rabbit carotids were exposed intraluminally either to peritoneal rabbit M phi, activated by 18 h of incubation with 1 microgram/ml lipopolysaccharide, or to the supernatants (SPN) derived from them. The contractile responses to phenylephrine (PE, 10(-6) M) were determined by measuring changes in diameter using an ultrasonic microdimensiometer 1, 2, and 3 h after the first control contraction. In control arteries (n = 12), PE-induced contractions were, respectively, 102.9 +/- 3.3%, 95.2 +/- 4.1%, and 89.7 +/- 3.8% of the first contraction, after 1, 2, and 3 h. Activated M phi significantly reduced PE-stimulated contractions after as little as 1 h of carotid exposure (percentage of controls at 1, 2, or 3 h: 74.1 +/- 5.6, 57.2 +/- 5.2, and 34.2 +/- 5.6, n = 10, P less than 0.001). The activated macrophage-derived SPN took longer to diminish carotid contractility than the M phi themselves, and became significant only after 2 h. The greater effect of M phi might be due to cooperation between M phi and vascular cells, as suggested by the amplified interleukin-1 release observed after M phi infusion. The presence of the endothelium partially protected carotid contractility from depression by activated M phi. Extraluminal addition of NG-monomethyl-L-arginine, an inhibitor of nitric oxide synthesis prevented this depression in arteries with or without endothelium. No products of the oxidative pathway of L-arginine were detected in rabbit activated M phi. These results suggest that activation of this pathway in smooth muscle cells seems to be involved in vascular hypocontractility. | lld:pubmed |
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| pubmed-article:1541677 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1541677 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1541677 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1541677 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1541677 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1541677 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:1541677 | pubmed:author | pubmed-author:BernardCC | lld:pubmed |
| pubmed-article:1541677 | pubmed:author | pubmed-author:WollmanEE | lld:pubmed |
| pubmed-article:1541677 | pubmed:author | pubmed-author:PhilipII | lld:pubmed |
| pubmed-article:1541677 | pubmed:author | pubmed-author:TedguiAA | lld:pubmed |
| pubmed-article:1541677 | pubmed:author | pubmed-author:PayenDD | lld:pubmed |
| pubmed-article:1541677 | pubmed:author | pubmed-author:SzekelyBB | lld:pubmed |
| pubmed-article:1541677 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1541677 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1541677 | pubmed:owner | NLM | lld:pubmed |
