| pubmed-article:1541547 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1541547 | lifeskim:mentions | umls-concept:C0021294 | lld:lifeskim |
| pubmed-article:1541547 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:1541547 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:1541547 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1541547 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1541547 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1541547 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1541547 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:1541547 | lifeskim:mentions | umls-concept:C0450254 | lld:lifeskim |
| pubmed-article:1541547 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1541547 | pubmed:dateCreated | 1992-4-3 | lld:pubmed |
| pubmed-article:1541547 | pubmed:abstractText | In the present study, a whole-blood culture was employed to examine the ability of preterm and term newborn infants to produce interleukin-6 (IL-6) in response to major bacterial pathogens such as group B streptococci, Escherichia coli, Listeria monocytogenes, and Streptococcus pneumoniae. Similarly, in response to stimulation with lipopolysaccharide, a potent stimulant for monocyte cytokine production, appreciable levels of IL-6 activity in the stimulated whole blood from term newborns as well as adults was effectively induced by all of these pathogens. In contrast to that of term infants, the bacteria-induced IL-6 production of preterm infants, especially those born before 30 weeks of gestation, was somewhat decreased (P less than 0.01 for each pathogen). It was also demonstrated that IL-6 responses to lipopolysaccharide stimulation were reduced in preterm newborns (for term versus preterm newborns less than 30 weeks of gestation, P was less than 0.01). These findings imply some inherent abnormality of monocytes in preterm babies. The diminished IL-6 production may be partly responsible for the susceptibility of preterm newborn infants to bacterial infections. | lld:pubmed |
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| pubmed-article:1541547 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1541547 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1541547 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1541547 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1541547 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1541547 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:1541547 | pubmed:author | pubmed-author:TaniguchiNN | lld:pubmed |
| pubmed-article:1541547 | pubmed:author | pubmed-author:TakanoNN | lld:pubmed |
| pubmed-article:1541547 | pubmed:author | pubmed-author:OhtaKK | lld:pubmed |
| pubmed-article:1541547 | pubmed:author | pubmed-author:FujitaSS | lld:pubmed |
| pubmed-article:1541547 | pubmed:author | pubmed-author:MiyawakiTT | lld:pubmed |
| pubmed-article:1541547 | pubmed:author | pubmed-author:UeharaTT | lld:pubmed |
| pubmed-article:1541547 | pubmed:author | pubmed-author:YachieAA | lld:pubmed |
| pubmed-article:1541547 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1541547 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:1541547 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1541547 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1541547 | pubmed:pagination | 749-53 | lld:pubmed |
| pubmed-article:1541547 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1541547 | pubmed:meshHeading | pubmed-meshheading:1541547-... | lld:pubmed |
| pubmed-article:1541547 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1541547 | pubmed:articleTitle | Defective production of interleukin-6 in very small premature infants in response to bacterial pathogens. | lld:pubmed |
| pubmed-article:1541547 | pubmed:affiliation | Department of Pediatrics, School of Medicine, Kanazawa University, Japan. | lld:pubmed |
| pubmed-article:1541547 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1541547 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1541547 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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