| pubmed-article:1541420 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1541420 | lifeskim:mentions | umls-concept:C0227354 | lld:lifeskim |
| pubmed-article:1541420 | lifeskim:mentions | umls-concept:C0021390 | lld:lifeskim |
| pubmed-article:1541420 | lifeskim:mentions | umls-concept:C0806987 | lld:lifeskim |
| pubmed-article:1541420 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:1541420 | lifeskim:mentions | umls-concept:C0487019 | lld:lifeskim |
| pubmed-article:1541420 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:1541420 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:1541420 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1541420 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:1541420 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:1541420 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:1541420 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1541420 | pubmed:dateCreated | 1992-4-3 | lld:pubmed |
| pubmed-article:1541420 | pubmed:abstractText | Increased concentrations of the soluble form of the interleukin 2 receptor have been observed in the sera of Crohn's disease and ulcerative colitis patients. In this study we have observed the spontaneous release of soluble interleukin 2 receptor by unstimulated, isolated normal and inflammatory bowel disease colonic lamina propria mononuclear cells. Lamina propria mononuclear cells from Crohn's disease patients (median = 204 U/ml (interquartile range 126-396, n 17) secreted significantly (p less than 0.01) more soluble interleukin 2 receptor than normal controls (median = 124.5 U/ml (108-131), n 12). No statistically significant differences were seen between ulcerative colitis (median = 135 U/ml (92-196), n 20) and normal controls. Moreover, significantly (p less than 0.01) increased amounts of soluble interleukin 2 receptor were secreted by colonic diverticulitis lamina propria mononuclear cells (median = 259 U/ml (149-282), n 15) which were used as disease specificity controls. Time course experiments showed that the majority of soluble interleukin 2 receptor was released by isolated lamina propria mononuclear cells in the first six days of culture. Upon stimulation with pokeweed mitogen, Crohn's disease (median = 2258 U/ml (1435-3584), n 14), normal control (median = 2622 U/ml (2030-3180), n 14) and diverticulitis lamina propria mononuclear cells (median = 2745 U/ml (1733-3192), n 10) reached similar maximal soluble interleukin 2 receptor secretion levels, while ulcerative colitis lamina propria mononuclear cells secreted significantly (p less than 0.005) less soluble interleukin 2 receptor (median = 912 U/ml (494-1259), n 17). These results suggest that enhanced shedding/secretion of soluble interleukin 2 receptor by intestinal lymphocytes may account in part for increased serum soluble interleukin 2 receptor concentrations during chronic intestinal inflammatory reactions. | lld:pubmed |
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| pubmed-article:1541420 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1541420 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1541420 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1541420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1541420 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1541420 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1541420 | pubmed:issn | 0017-5749 | lld:pubmed |
| pubmed-article:1541420 | pubmed:author | pubmed-author:MacDermottR... | lld:pubmed |
| pubmed-article:1541420 | pubmed:author | pubmed-author:SchreiberSS | lld:pubmed |
| pubmed-article:1541420 | pubmed:author | pubmed-author:RaedlerAA | lld:pubmed |
| pubmed-article:1541420 | pubmed:author | pubmed-author:RombeauJ LJL | lld:pubmed |
| pubmed-article:1541420 | pubmed:author | pubmed-author:ConnA RAR | lld:pubmed |
| pubmed-article:1541420 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1541420 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:1541420 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1541420 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1541420 | pubmed:pagination | 236-41 | lld:pubmed |
| pubmed-article:1541420 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1541420 | pubmed:meshHeading | pubmed-meshheading:1541420-... | lld:pubmed |
| pubmed-article:1541420 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1541420 | pubmed:articleTitle | Increased in vitro release of soluble interleukin 2 receptor by colonic lamina propria mononuclear cells in inflammatory bowel disease. | lld:pubmed |
| pubmed-article:1541420 | pubmed:affiliation | University of Pennsylvania, Gastrointestinal Section, Philadelphia, PA. | lld:pubmed |
| pubmed-article:1541420 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1541420 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1541420 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1541420 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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