Linked Life Data

15389830

Source:http://linkedlifedata.com/resource/pubmed/id/15389830

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15389830rdf:typepubmed:Citationlld:pubmed
pubmed-article:15389830lifeskim:mentionsumls-concept:C0032961lld:lifeskim
pubmed-article:15389830lifeskim:mentionsumls-concept:C1858460lld:lifeskim
pubmed-article:15389830lifeskim:mentionsumls-concept:C0270611lld:lifeskim
pubmed-article:15389830lifeskim:mentionsumls-concept:C0521457lld:lifeskim
pubmed-article:15389830lifeskim:mentionsumls-concept:C0024480lld:lifeskim
pubmed-article:15389830lifeskim:mentionsumls-concept:C0242184lld:lifeskim
pubmed-article:15389830lifeskim:mentionsumls-concept:C1545588lld:lifeskim
pubmed-article:15389830lifeskim:mentionsumls-concept:C0205263lld:lifeskim
pubmed-article:15389830lifeskim:mentionsumls-concept:C0728938lld:lifeskim
pubmed-article:15389830pubmed:issue3lld:pubmed
pubmed-article:15389830pubmed:dateCreated2004-10-20lld:pubmed
pubmed-article:15389830pubmed:abstractTextFetal low brain oxygenation may be an outcome of maternal complications during pregnancy and is associated with increased risk of cerebral palsy and periventricular leukomalacia in newborns. One treatment used for prevention of fetal brain damage is maternal treatment with MgSO(4). Although this treatment is indicated to reduce the risk of cerebral palsy in newborns, its use remains controversial. We have shown previously that pretreatment with MgSO(4) in a mouse model of maternal hypoxia prevented a delay in the development of motor reflexes induced by hypoxia. We demonstrate here that pretreatment with MgSO(4) reduces hypoxia-induced motor disabilities in adult offspring. This effect is associated with histologic protection of the Purkinje cells in the cerebellum and stabilization of brain-derived neurotrophic factor (BDNF) levels in the cerebellum. MgSO(4) did not prevent the reduction in cerebral cortex cell density and cell size induced by maternal hypoxia, however, nor did it interfere with the modulation of BDNF and nerve growth factor (NGF) expression in the cerebral cortex. MgSO(4) pretreatment also prevented the impairment of short-term memory (30 min, P < 0.05) but not long-term memory (7 days). Nevertheless, maternal pretreatment with MgSO(4) reduced CA1 cell layer width and induced alterations in both NGF and BDNF in the hippocampus. These results support the prophylactic effect of MgSO(4) against motor disabilities; however, they may also indicate possible harmful effects on the cerebral cortex and hippocampus.lld:pubmed
pubmed-article:15389830pubmed:languageenglld:pubmed
pubmed-article:15389830pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15389830pubmed:citationSubsetIMlld:pubmed
pubmed-article:15389830pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15389830pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15389830pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15389830pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15389830pubmed:statusMEDLINElld:pubmed
pubmed-article:15389830pubmed:monthNovlld:pubmed
pubmed-article:15389830pubmed:issn0360-4012lld:pubmed
pubmed-article:15389830pubmed:authorpubmed-author:SorokinYYlld:pubmed
pubmed-article:15389830pubmed:authorpubmed-author:HallalJJlld:pubmed
pubmed-article:15389830pubmed:authorpubmed-author:GolanHHlld:pubmed
pubmed-article:15389830pubmed:authorpubmed-author:HuleihelMMlld:pubmed
pubmed-article:15389830pubmed:authorpubmed-author:KashtuzkiIIlld:pubmed
pubmed-article:15389830pubmed:copyrightInfoCopyright 2004 Wiley-Liss, Inc.lld:pubmed
pubmed-article:15389830pubmed:issnTypePrintlld:pubmed
pubmed-article:15389830pubmed:day1lld:pubmed
pubmed-article:15389830pubmed:volume78lld:pubmed
pubmed-article:15389830pubmed:ownerNLMlld:pubmed
pubmed-article:15389830pubmed:authorsCompleteYlld:pubmed
pubmed-article:15389830pubmed:pagination430-41lld:pubmed
pubmed-article:15389830pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:meshHeadingpubmed-meshheading:15389830...lld:pubmed
pubmed-article:15389830pubmed:year2004lld:pubmed
pubmed-article:15389830pubmed:articleTitleMaternal hypoxia during pregnancy induces fetal neurodevelopmental brain damage: partial protection by magnesium sulfate.lld:pubmed
pubmed-article:15389830pubmed:affiliationDepartment of Developmental Molecular Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. havag@bgumail.bgu.ac.illld:pubmed
pubmed-article:15389830pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15389830pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:15389830pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15389830lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15389830lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15389830lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15389830lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15389830lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15389830lld:pubmed