| pubmed-article:15385730 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15385730 | lifeskim:mentions | umls-concept:C0007807 | lld:lifeskim |
| pubmed-article:15385730 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15385730 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15385730 | pubmed:dateCreated | 2004-9-23 | lld:pubmed |
| pubmed-article:15385730 | pubmed:abstractText | In HIV-1-infected subjects, the magnitude of HIV-1 viral load in cerebrospinal fluid (CSF) correlates with the CSF white cell count. To determine whether HIV-1-producing T cells appear in CSF and whether their percentage and number correlate with viral load in CSF, we developed a flow cytometric assay that detects HIV-1-producing T cells by identifying intracellular p24 HIV-1 antigen. We found that most CSF T cells were not HIV-1 producing, even when cell-free viral load in CSF was high. Most activated T cells in CSF were also not HIV-1 producing, but the activated CD38+ CD4 T-cell fraction in CSF was independently associated with the fraction of HIV-1-producing T cells in CSF. We conclude that HIV-1-producing T cells appear in CSF and that their percentage and number correlate with cell-free viral load in CSF, even though the CSF total white cell count remains the best predictor for CSF viral load. In HIV-1 infection, CSF white cell counts seem to contain a large number of uninfected cells. White cell counts and viral load in CSF may result from systemic inflammation and immune activation. | lld:pubmed |
| pubmed-article:15385730 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15385730 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15385730 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15385730 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15385730 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15385730 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15385730 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15385730 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15385730 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15385730 | pubmed:issn | 1525-4135 | lld:pubmed |
| pubmed-article:15385730 | pubmed:author | pubmed-author:BacchettiPete... | lld:pubmed |
| pubmed-article:15385730 | pubmed:author | pubmed-author:GrantRobert... | lld:pubmed |
| pubmed-article:15385730 | pubmed:author | pubmed-author:PriceRichard... | lld:pubmed |
| pubmed-article:15385730 | pubmed:author | pubmed-author:SinclairEliza... | lld:pubmed |
| pubmed-article:15385730 | pubmed:author | pubmed-author:NeuenburgJutt... | lld:pubmed |
| pubmed-article:15385730 | pubmed:author | pubmed-author:NilssonAnneli... | lld:pubmed |
| pubmed-article:15385730 | pubmed:author | pubmed-author:KreisChristop... | lld:pubmed |
| pubmed-article:15385730 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15385730 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15385730 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:15385730 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15385730 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15385730 | pubmed:pagination | 1237-44 | lld:pubmed |
| pubmed-article:15385730 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15385730 | pubmed:meshHeading | pubmed-meshheading:15385730... | lld:pubmed |
| pubmed-article:15385730 | pubmed:meshHeading | pubmed-meshheading:15385730... | lld:pubmed |
| pubmed-article:15385730 | pubmed:meshHeading | pubmed-meshheading:15385730... | lld:pubmed |
| pubmed-article:15385730 | pubmed:meshHeading | pubmed-meshheading:15385730... | lld:pubmed |
| pubmed-article:15385730 | pubmed:meshHeading | pubmed-meshheading:15385730... | lld:pubmed |
| pubmed-article:15385730 | pubmed:meshHeading | pubmed-meshheading:15385730... | lld:pubmed |
| pubmed-article:15385730 | pubmed:meshHeading | pubmed-meshheading:15385730... | lld:pubmed |
| pubmed-article:15385730 | pubmed:meshHeading | pubmed-meshheading:15385730... | lld:pubmed |
| pubmed-article:15385730 | pubmed:meshHeading | pubmed-meshheading:15385730... | lld:pubmed |
| pubmed-article:15385730 | pubmed:meshHeading | pubmed-meshheading:15385730... | lld:pubmed |
| pubmed-article:15385730 | pubmed:meshHeading | pubmed-meshheading:15385730... | lld:pubmed |
| pubmed-article:15385730 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15385730 | pubmed:articleTitle | HIV-producing T cells in cerebrospinal fluid. | lld:pubmed |
| pubmed-article:15385730 | pubmed:affiliation | Gladstone Institute of Virology and Immunology, San Francisco, CA, USA. | lld:pubmed |
| pubmed-article:15385730 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15385730 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15385730 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15385730 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15385730 | lld:pubmed |
