| pubmed-article:15380820 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15380820 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:15380820 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15380820 | lifeskim:mentions | umls-concept:C2340138 | lld:lifeskim |
| pubmed-article:15380820 | lifeskim:mentions | umls-concept:C0012472 | lld:lifeskim |
| pubmed-article:15380820 | lifeskim:mentions | umls-concept:C0033567 | lld:lifeskim |
| pubmed-article:15380820 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15380820 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:15380820 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15380820 | pubmed:dateCreated | 2004-9-21 | lld:pubmed |
| pubmed-article:15380820 | pubmed:abstractText | Hepatic stellate cells (HSC) are central to liver fibrosis. The eicosanoid pathway and cyclooxygenase-2 (COX-2) may be an important signaling mechanism in HSC. We investigated the role of COX-2, prostaglandin E(2) (PGE(2)) and prostaglandin I(2) (PGI(2)) in proliferation of LI90, an immortalized cell line of HSC. Our results showed that COX-2 was upregulated by platelet-derived growth factor (PDGF), a mitogen in HSC. COX-2 was responsible for the production of PGE(2) and PGI(2) in PDGF-stimulated LI90 cells. Furthermore, we demonstrated that COX-2 and PGE(2) mediated the proliferative response of LI90 to PDGF while synthetic analogue of PGI(2) exhibited anti-proliferative effect. Our findings suggest complex interactions of prostaglandins in liver fibrogenesis. In vivo studies using animal models are needed to elucidate the effect of COX-2 inhibition by non-steroidal anti-inflammatory drugs or COX-2 inhibitor in hepatic fibrosis. | lld:pubmed |
| pubmed-article:15380820 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15380820 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380820 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15380820 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380820 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380820 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380820 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380820 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380820 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380820 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380820 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15380820 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15380820 | pubmed:issn | 0952-3278 | lld:pubmed |
| pubmed-article:15380820 | pubmed:author | pubmed-author:SataMichioM | lld:pubmed |
| pubmed-article:15380820 | pubmed:author | pubmed-author:ChanHenry... | lld:pubmed |
| pubmed-article:15380820 | pubmed:author | pubmed-author:SungJoseph... | lld:pubmed |
| pubmed-article:15380820 | pubmed:author | pubmed-author:HuiAlex YuiAY | lld:pubmed |
| pubmed-article:15380820 | pubmed:author | pubmed-author:UenoTakatoT | lld:pubmed |
| pubmed-article:15380820 | pubmed:author | pubmed-author:ChanFrancis... | lld:pubmed |
| pubmed-article:15380820 | pubmed:author | pubmed-author:SakataRyuichi... | lld:pubmed |
| pubmed-article:15380820 | pubmed:author | pubmed-author:ChengAlfred... | lld:pubmed |
| pubmed-article:15380820 | pubmed:author | pubmed-author:GoMinnie... | lld:pubmed |
| pubmed-article:15380820 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15380820 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:15380820 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15380820 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15380820 | pubmed:pagination | 329-33 | lld:pubmed |
| pubmed-article:15380820 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15380820 | pubmed:meshHeading | pubmed-meshheading:15380820... | lld:pubmed |
| pubmed-article:15380820 | pubmed:meshHeading | pubmed-meshheading:15380820... | lld:pubmed |
| pubmed-article:15380820 | pubmed:meshHeading | pubmed-meshheading:15380820... | lld:pubmed |
| pubmed-article:15380820 | pubmed:meshHeading | pubmed-meshheading:15380820... | lld:pubmed |
| pubmed-article:15380820 | pubmed:meshHeading | pubmed-meshheading:15380820... | lld:pubmed |
| pubmed-article:15380820 | pubmed:meshHeading | pubmed-meshheading:15380820... | lld:pubmed |
| pubmed-article:15380820 | pubmed:meshHeading | pubmed-meshheading:15380820... | lld:pubmed |
| pubmed-article:15380820 | pubmed:meshHeading | pubmed-meshheading:15380820... | lld:pubmed |
| pubmed-article:15380820 | pubmed:meshHeading | pubmed-meshheading:15380820... | lld:pubmed |
| pubmed-article:15380820 | pubmed:meshHeading | pubmed-meshheading:15380820... | lld:pubmed |
| pubmed-article:15380820 | pubmed:meshHeading | pubmed-meshheading:15380820... | lld:pubmed |
| pubmed-article:15380820 | pubmed:meshHeading | pubmed-meshheading:15380820... | lld:pubmed |
| pubmed-article:15380820 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15380820 | pubmed:articleTitle | Effect of prostaglandin E2 and prostaglandin I2 on PDGF-induced proliferation of LI90, a human hepatic stellate cell line. | lld:pubmed |
| pubmed-article:15380820 | pubmed:affiliation | Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong. alexyhui@yahoo.com | lld:pubmed |
| pubmed-article:15380820 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15380820 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
