| pubmed-article:15374884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15374884 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:15374884 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:15374884 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
| pubmed-article:15374884 | lifeskim:mentions | umls-concept:C1977882 | lld:lifeskim |
| pubmed-article:15374884 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:15374884 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15374884 | lifeskim:mentions | umls-concept:C1881488 | lld:lifeskim |
| pubmed-article:15374884 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15374884 | pubmed:dateCreated | 2005-2-17 | lld:pubmed |
| pubmed-article:15374884 | pubmed:abstractText | We have previously reported that chaperonerich cell lysates (CRCL) derived from the BCR-ABL+ 12B1 leukemia activate dendritic cells (DCs) and stimulate leukemia-specific immune responses. Because CRCL contain a variety of heat shock/chaperone proteins, we theorized that CRCL obtained from BCR-ABL+ leukemias are likely to chaperone BCR-ABL-derived fusion peptides and that DCs pulsed with 12B1 CRCL could cross-present BCR-ABL fusion peptides to T cells. We found that splenocytes from mice vaccinated with BCR-ABL+ leukemia-derived CRCL secreted interferon-gamma (IFN-gamma) when restimulated with a BCR-ABL peptide, GFKQSSKAL, indicating that BCR-ABL peptides are chaperoned by leukemia-derived CRCL. We next eluted peptides from 12B1 leukemia-derived CRCL and used high-pressure liquid chromatography (HPLC) fractions to restimulate splenocytes harvested from mice vaccinated with DC/GFKQSSKAL or DC/12B1 CRCL. We found that the same peptide fractions derived from 12B1 CRCL and from "refractionated" GFKQSSKAL stimulated IFN-gamma production, suggesting the presence of BCR-ABL peptides in the peptide repertoire of 12B1 CRCL. We also demonstrated that immunization with DCs loaded with leukemia-derived CRCL induced BCR-ABL-specific cytotoxic T lymphocytes (CTLs) in vivo. Moreover, mice immunized with DCs pulsed with 12B1-derived CRCL had superior survival (60%) when compared with those immunized with DCs pulsed with BCR-ABL peptide (20%), indicating that CRCL vaccines provide additional immune stimulus over and above individual peptide vaccination. | lld:pubmed |
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| pubmed-article:15374884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15374884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15374884 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15374884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15374884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15374884 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15374884 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:15374884 | pubmed:author | pubmed-author:ZengYiY | lld:pubmed |
| pubmed-article:15374884 | pubmed:author | pubmed-author:GranerMichael... | lld:pubmed |
| pubmed-article:15374884 | pubmed:author | pubmed-author:KatsanisEmman... | lld:pubmed |
| pubmed-article:15374884 | pubmed:author | pubmed-author:ThompsonSylvi... | lld:pubmed |
| pubmed-article:15374884 | pubmed:author | pubmed-author:MarronMarilyn... | lld:pubmed |
| pubmed-article:15374884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15374884 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15374884 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:15374884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15374884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15374884 | pubmed:pagination | 2016-22 | lld:pubmed |
| pubmed-article:15374884 | pubmed:dateRevised | 2011-2-23 | lld:pubmed |
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