| pubmed-article:15371430 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15371430 | lifeskim:mentions | umls-concept:C0600253 | lld:lifeskim |
| pubmed-article:15371430 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15371430 | lifeskim:mentions | umls-concept:C1332713 | lld:lifeskim |
| pubmed-article:15371430 | lifeskim:mentions | umls-concept:C1415831 | lld:lifeskim |
| pubmed-article:15371430 | lifeskim:mentions | umls-concept:C1428747 | lld:lifeskim |
| pubmed-article:15371430 | lifeskim:mentions | umls-concept:C2239666 | lld:lifeskim |
| pubmed-article:15371430 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:15371430 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:15371430 | lifeskim:mentions | umls-concept:C1159825 | lld:lifeskim |
| pubmed-article:15371430 | pubmed:issue | 49 | lld:pubmed |
| pubmed-article:15371430 | pubmed:dateCreated | 2004-11-25 | lld:pubmed |
| pubmed-article:15371430 | pubmed:abstractText | Inhibitor of apoptosis (IAP) proteins are involved in the suppression of apoptosis, signal transduction, cell cycle control and gene regulation. Here we describe the cloning and characterization of viral IAP-associated factor (VIAF), a highly conserved, ubiquitously expressed phosphoprotein with limited homology to members of the phosducin family that associates with baculovirus Op-IAP. VIAF bound Op-IAP both in vitro and in intact cells, with each protein displaying a predominantly cytoplasmic localization. VIAF lacks a consensus IAP binding motif, and overexpression of VIAF failed to prevent Op-IAP from protecting human cells from a variety of apoptotic stimuli, suggesting that VIAF does not function as an IAP antagonist. VIAF was unable to directly inhibit caspase activation in vitro and a reduction of VIAF protein levels by RNA interference led to a decrease in Bax-mediated caspase activation, suggesting that VIAF functions to co-regulate the apoptotic cascade. Finally, VIAF is a substrate for ubiquitination mediated by Op-IAP. Thus, VIAF is a novel IAP-interacting factor that functions in caspase activation during apoptosis. | lld:pubmed |
| pubmed-article:15371430 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15371430 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371430 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15371430 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15371430 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15371430 | pubmed:author | pubmed-author:WilkinsonJohn... | lld:pubmed |
| pubmed-article:15371430 | pubmed:author | pubmed-author:DuckettColin... | lld:pubmed |
| pubmed-article:15371430 | pubmed:author | pubmed-author:RumbleJulie... | lld:pubmed |
| pubmed-article:15371430 | pubmed:author | pubmed-author:WilkinsonAman... | lld:pubmed |
| pubmed-article:15371430 | pubmed:author | pubmed-author:BursteinEzraE | lld:pubmed |
| pubmed-article:15371430 | pubmed:author | pubmed-author:RichterBettin... | lld:pubmed |
| pubmed-article:15371430 | pubmed:author | pubmed-author:BalliuBlerina... | lld:pubmed |
| pubmed-article:15371430 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15371430 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:15371430 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:15371430 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15371430 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15371430 | pubmed:pagination | 51091-9 | lld:pubmed |
| pubmed-article:15371430 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15371430 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15371430 | pubmed:articleTitle | VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. | lld:pubmed |
| pubmed-article:15371430 | pubmed:affiliation | Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA. | lld:pubmed |
| pubmed-article:15371430 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15371430 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15371430 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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