| pubmed-article:15365786 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15365786 | lifeskim:mentions | umls-concept:C0034143 | lld:lifeskim |
| pubmed-article:15365786 | lifeskim:mentions | umls-concept:C0034837 | lld:lifeskim |
| pubmed-article:15365786 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:15365786 | lifeskim:mentions | umls-concept:C0064997 | lld:lifeskim |
| pubmed-article:15365786 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15365786 | pubmed:dateCreated | 2005-1-19 | lld:pubmed |
| pubmed-article:15365786 | pubmed:abstractText | Linalool is a major component of essential oils and possesses various biological effects in sensory or central nervous systems. To investigate the pharmacological and biophysical effects of linalool on voltage-gated currents in sensory neurons, we used the whole-cell patch clamp and the Ca(2+) imaging techniques. Under the voltage clamp, membrane depolarization generated time- and voltage-dependent current responses in newt olfactory receptor cells (ORCs). Linalool significantly and reversibly suppressed the voltage-gated currents in ORCs. The dose-suppression relation of linalool for the voltage-gated Na(+) current could be fitted by the Hill equation with a half-blocking concentration of 0.56 mM and a Hill coefficient of 1.2. To test whether linalool suppresses voltage-gated currents in ORCs specifically or suppresses currents in other neurons generally, we next examined the effects of linalool on voltage-gated currents in newt retinal neurons and rat cerebellar Purkinje cells. Linalool suppressed the voltage-gated currents not only in retinal horizontal cells and ganglion cells but also in Purkinje cells. Furthermore, bath application of linalool inhibited the KCl-induced [Ca(2+)](i) response of ORCs, suggesting that linalool suppresses Ca(2+) currents in ORCs. These results suggest that linalool non-selectively suppresses the voltage-gated currents in newt sensory neurons and rat cerebellar Purkinje cells. | lld:pubmed |
| pubmed-article:15365786 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15365786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15365786 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15365786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15365786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15365786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15365786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15365786 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15365786 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15365786 | pubmed:issn | 0300-9564 | lld:pubmed |
| pubmed-article:15365786 | pubmed:author | pubmed-author:KawaiFF | lld:pubmed |
| pubmed-article:15365786 | pubmed:author | pubmed-author:MatsuzakiKK | lld:pubmed |
| pubmed-article:15365786 | pubmed:author | pubmed-author:MiyachiEE | lld:pubmed |
| pubmed-article:15365786 | pubmed:author | pubmed-author:NarusuyeKK | lld:pubmed |
| pubmed-article:15365786 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15365786 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:15365786 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15365786 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15365786 | pubmed:pagination | 193-203 | lld:pubmed |
| pubmed-article:15365786 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15365786 | pubmed:meshHeading | pubmed-meshheading:15365786... | lld:pubmed |
| pubmed-article:15365786 | pubmed:meshHeading | pubmed-meshheading:15365786... | lld:pubmed |
| pubmed-article:15365786 | pubmed:meshHeading | pubmed-meshheading:15365786... | lld:pubmed |
| pubmed-article:15365786 | pubmed:meshHeading | pubmed-meshheading:15365786... | lld:pubmed |
| pubmed-article:15365786 | pubmed:meshHeading | pubmed-meshheading:15365786... | lld:pubmed |
| pubmed-article:15365786 | pubmed:meshHeading | pubmed-meshheading:15365786... | lld:pubmed |
| pubmed-article:15365786 | pubmed:meshHeading | pubmed-meshheading:15365786... | lld:pubmed |
| pubmed-article:15365786 | pubmed:meshHeading | pubmed-meshheading:15365786... | lld:pubmed |
| pubmed-article:15365786 | pubmed:meshHeading | pubmed-meshheading:15365786... | lld:pubmed |
| pubmed-article:15365786 | pubmed:meshHeading | pubmed-meshheading:15365786... | lld:pubmed |
| pubmed-article:15365786 | pubmed:meshHeading | pubmed-meshheading:15365786... | lld:pubmed |
| pubmed-article:15365786 | pubmed:meshHeading | pubmed-meshheading:15365786... | lld:pubmed |
| pubmed-article:15365786 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15365786 | pubmed:articleTitle | Linalool suppresses voltage-gated currents in sensory neurons and cerebellar Purkinje cells. | lld:pubmed |
| pubmed-article:15365786 | pubmed:affiliation | Department of Physiology, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan. | lld:pubmed |
| pubmed-article:15365786 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15365786 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15365786 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
