| pubmed-article:15365096 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15365096 | lifeskim:mentions | umls-concept:C0019693 | lld:lifeskim |
| pubmed-article:15365096 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15365096 | lifeskim:mentions | umls-concept:C0017189 | lld:lifeskim |
| pubmed-article:15365096 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15365096 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:15365096 | lifeskim:mentions | umls-concept:C1709305 | lld:lifeskim |
| pubmed-article:15365096 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:15365096 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15365096 | pubmed:dateCreated | 2004-9-21 | lld:pubmed |
| pubmed-article:15365096 | pubmed:abstractText | The mechanisms underlying CD4(+) T cell depletion in human immunodeficiency virus (HIV) infection are not well understood. Comparative studies of lymphoid tissues, where the vast majority of T cells reside, and peripheral blood can potentially illuminate the pathogenesis of HIV-associated disease. Here, we studied the effect of HIV infection on the activation and depletion of defined subsets of CD4(+) and CD8(+) T cells in the blood, gastrointestinal (GI) tract, and lymph node (LN). We also measured HIV-specific T cell frequencies in LNs and blood, and LN collagen deposition to define architectural changes associated with chronic inflammation. The major findings to emerge are the following: the GI tract has the most substantial CD4(+) T cell depletion at all stages of HIV disease; this depletion occurs preferentially within CCR5(+) CD4(+) T cells; HIV-associated immune activation results in abnormal accumulation of effector-type T cells within LNs; HIV-specific T cells in LNs do not account for all effector T cells; and T cell activation in LNs is associated with abnormal collagen deposition. Taken together, these findings define the nature and extent of CD4(+) T cell depletion in lymphoid tissue and point to mechanisms of profound depletion of specific T cell subsets related to elimination of CCR5(+) CD4(+) T cell targets and disruption of T cell homeostasis that accompanies chronic immune activation. | lld:pubmed |
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| pubmed-article:15365096 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15365096 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15365096 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15365096 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15365096 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15365096 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:15365096 | pubmed:author | pubmed-author:SchackerTimot... | lld:pubmed |
| pubmed-article:15365096 | pubmed:author | pubmed-author:BrenchleyJaso... | lld:pubmed |
| pubmed-article:15365096 | pubmed:author | pubmed-author:DouekDaniel... | lld:pubmed |
| pubmed-article:15365096 | pubmed:author | pubmed-author:PriceDavid... | lld:pubmed |
| pubmed-article:15365096 | pubmed:author | pubmed-author:HaaseAshley... | lld:pubmed |
| pubmed-article:15365096 | pubmed:author | pubmed-author:NguyenPhuong... | lld:pubmed |
| pubmed-article:15365096 | pubmed:author | pubmed-author:BeilmanGregor... | lld:pubmed |
| pubmed-article:15365096 | pubmed:author | pubmed-author:LarsonMatthew... | lld:pubmed |
| pubmed-article:15365096 | pubmed:author | pubmed-author:KhorutsAlexan... | lld:pubmed |
| pubmed-article:15365096 | pubmed:author | pubmed-author:TaylorJodie... | lld:pubmed |
| pubmed-article:15365096 | pubmed:author | pubmed-author:RuffLaura ELE | lld:pubmed |
| pubmed-article:15365096 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15365096 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:15365096 | pubmed:volume | 200 | lld:pubmed |
| pubmed-article:15365096 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15365096 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15365096 | pubmed:pagination | 749-59 | lld:pubmed |
| pubmed-article:15365096 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15365096 | pubmed:meshHeading | pubmed-meshheading:15365096... | lld:pubmed |
