| pubmed-article:15363409 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15363409 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:15363409 | lifeskim:mentions | umls-concept:C0205094 | lld:lifeskim |
| pubmed-article:15363409 | lifeskim:mentions | umls-concept:C1414681 | lld:lifeskim |
| pubmed-article:15363409 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:15363409 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:15363409 | lifeskim:mentions | umls-concept:C1521738 | lld:lifeskim |
| pubmed-article:15363409 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15363409 | pubmed:dateCreated | 2004-9-14 | lld:pubmed |
| pubmed-article:15363409 | pubmed:abstractText | The anterior heart field (AHF) mediates formation of the outflow tract (OFT) and right ventricle (RV) during looping morphogenesis of the heart. Foxh1 is a forkhead DNA binding transcription factor in the TGFbeta-Smad pathway. Here we demonstrate that Foxh1-/- mutant mouse embryos form a primitive heart tube, but fail to form OFT and RV and display loss of outer curvature markers of the future working myocardium, similar to the phenotype of Mef2c-/- mutant hearts. Further, we show that Mef2c is a direct target of Foxh1, which physically and functionally interacts with Nkx2-5 to mediate strong Smad-dependent activation of a TGFbeta response element in the Mef2c gene. This element directs transgene expression to the presumptive AHF, as well as the RV and OFT, a pattern that closely parallels endogenous Mef2c expression in the heart. Thus, Foxh1 and Nkx2-5 functionally interact and are essential for development of the AHF and its derivatives, the RV and OFT, in response to TGFbeta-like signals. | lld:pubmed |
| pubmed-article:15363409 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15363409 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15363409 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15363409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15363409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15363409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15363409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15363409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15363409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15363409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15363409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15363409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15363409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15363409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15363409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15363409 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15363409 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15363409 | pubmed:issn | 1534-5807 | lld:pubmed |
| pubmed-article:15363409 | pubmed:author | pubmed-author:HarveyRichard... | lld:pubmed |
| pubmed-article:15363409 | pubmed:author | pubmed-author:WranaJeffrey... | lld:pubmed |
| pubmed-article:15363409 | pubmed:author | pubmed-author:ErdemirTubaT | lld:pubmed |
| pubmed-article:15363409 | pubmed:author | pubmed-author:RossantJanetJ | lld:pubmed |
| pubmed-article:15363409 | pubmed:author | pubmed-author:HenkelmanR... | lld:pubmed |
| pubmed-article:15363409 | pubmed:author | pubmed-author:AttisanoLilia... | lld:pubmed |
| pubmed-article:15363409 | pubmed:author | pubmed-author:LickertHeikoH | lld:pubmed |
| pubmed-article:15363409 | pubmed:author | pubmed-author:von BothIngoI | lld:pubmed |
| pubmed-article:15363409 | pubmed:author | pubmed-author:SilvestriCris... | lld:pubmed |
| pubmed-article:15363409 | pubmed:author | pubmed-author:WallsJohnatho... | lld:pubmed |
| pubmed-article:15363409 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15363409 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:15363409 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15363409 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15363409 | pubmed:pagination | 331-45 | lld:pubmed |
| pubmed-article:15363409 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15363409 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15363409 | pubmed:articleTitle | Foxh1 is essential for development of the anterior heart field. | lld:pubmed |
| pubmed-article:15363409 | pubmed:affiliation | Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada. | lld:pubmed |
| pubmed-article:15363409 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15363409 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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