| pubmed-article:15361250 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15361250 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:15361250 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15361250 | lifeskim:mentions | umls-concept:C0023283 | lld:lifeskim |
| pubmed-article:15361250 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:15361250 | lifeskim:mentions | umls-concept:C0597634 | lld:lifeskim |
| pubmed-article:15361250 | pubmed:dateCreated | 2004-9-13 | lld:pubmed |
| pubmed-article:15361250 | pubmed:abstractText | Leishmania major infections induce the development of a CD4(+) T-helper 1 (Th1) response that not only controls the primary infection but also results in life-long immunity to reinfection. How that immunity is maintained is unknown, although because of the existence of infection-induced immunity, there has been an assumption that the development of a vaccine against leishmaniasis would be relatively easy. This has turned out not to be the case. One problem has been the finding that a large part of the immunity induced by a primary infection depends upon the presence of persistent parasites. Nevertheless, there are ample situations where immunologic memory persists without the continued presence of antigen, providing the prospect that a non-live vaccine for leishmaniasis can be developed. To do so will require an understanding of the events involved in the development of an effective protective T-cell response and, more importantly, an understanding of how to maintain that response. Here, we review work from our laboratory, describing how Th1 cells develop in L. major-infected mice, the nature of the memory T cells that provide protection to reinfection, and how that information may be utilized in the development of vaccines. | lld:pubmed |
| pubmed-article:15361250 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15361250 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15361250 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15361250 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15361250 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15361250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15361250 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15361250 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15361250 | pubmed:issn | 0105-2896 | lld:pubmed |
| pubmed-article:15361250 | pubmed:author | pubmed-author:ScottPhillipP | lld:pubmed |
| pubmed-article:15361250 | pubmed:author | pubmed-author:ArtisDavidD | lld:pubmed |
| pubmed-article:15361250 | pubmed:author | pubmed-author:ZaphColbyC | lld:pubmed |
| pubmed-article:15361250 | pubmed:author | pubmed-author:UzonnaJudeJ | lld:pubmed |
| pubmed-article:15361250 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15361250 | pubmed:volume | 201 | lld:pubmed |
| pubmed-article:15361250 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15361250 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15361250 | pubmed:pagination | 318-38 | lld:pubmed |
| pubmed-article:15361250 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15361250 | pubmed:meshHeading | pubmed-meshheading:15361250... | lld:pubmed |
| pubmed-article:15361250 | pubmed:meshHeading | pubmed-meshheading:15361250... | lld:pubmed |
| pubmed-article:15361250 | pubmed:meshHeading | pubmed-meshheading:15361250... | lld:pubmed |
| pubmed-article:15361250 | pubmed:meshHeading | pubmed-meshheading:15361250... | lld:pubmed |
| pubmed-article:15361250 | pubmed:meshHeading | pubmed-meshheading:15361250... | lld:pubmed |
| pubmed-article:15361250 | pubmed:meshHeading | pubmed-meshheading:15361250... | lld:pubmed |
| pubmed-article:15361250 | pubmed:meshHeading | pubmed-meshheading:15361250... | lld:pubmed |
| pubmed-article:15361250 | pubmed:meshHeading | pubmed-meshheading:15361250... | lld:pubmed |
| pubmed-article:15361250 | pubmed:meshHeading | pubmed-meshheading:15361250... | lld:pubmed |
| pubmed-article:15361250 | pubmed:meshHeading | pubmed-meshheading:15361250... | lld:pubmed |
| pubmed-article:15361250 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15361250 | pubmed:articleTitle | The development of effector and memory T cells in cutaneous leishmaniasis: the implications for vaccine development. | lld:pubmed |
| pubmed-article:15361250 | pubmed:affiliation | Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. pscott@vet.upenn.edu | lld:pubmed |
| pubmed-article:15361250 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15361250 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15361250 | pubmed:publicationType | Review | lld:pubmed |
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