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pubmed-article:15356565pubmed:abstractTextProgress in peptide immunotherapy for the treatment of autoimmune diseases has been hampered by reports of anaphylactic reactions in both mice and human subjects. Fatal anaphylaxis in nonobese diabetic (NOD) mice has been described after repeated subcutaneous insulin peptide B:9-23 immunizations. On the basis of observations that rapid systemic delivery of peptide to a sensitized mouse (eg, intravenous delivery) increases the anaphylactic response, it was hypothesized that slowing down the absorption of the peptide would prevent anaphylaxis.lld:pubmed
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pubmed-article:15356565pubmed:articleTitlePreventing peptide-induced anaphylaxis: addition of C-terminal amino acids to produce a neutral isoelectric point.lld:pubmed
pubmed-article:15356565pubmed:affiliationSection of Gastroenterology, Hepatology and Nutrition, The Children's Hospital, Denver, Colorado, USA. Edwin.liu@uchsc.edulld:pubmed
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