| pubmed-article:1535284 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1535284 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:1535284 | lifeskim:mentions | umls-concept:C0038856 | lld:lifeskim |
| pubmed-article:1535284 | lifeskim:mentions | umls-concept:C0021080 | lld:lifeskim |
| pubmed-article:1535284 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:1535284 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:1535284 | lifeskim:mentions | umls-concept:C0021079 | lld:lifeskim |
| pubmed-article:1535284 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:1535284 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1535284 | lifeskim:mentions | umls-concept:C1519667 | lld:lifeskim |
| pubmed-article:1535284 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1535284 | pubmed:dateCreated | 1992-7-28 | lld:pubmed |
| pubmed-article:1535284 | pubmed:abstractText | Normal bone marrow cells become immunosuppressive when cultured with supernatants of metastatic Lewis lung carcinoma (LLC-LN7) cells. The suppressor-inducing activities in the LLC-LN7 supernatants are interleukin-3 and granulocyte/macrophage-colony-stimulating factor. In the present study, the mechanisms by which these induced suppressor cells (LLCsup-BM) mediate their immunosuppression were investigated. The suppression by LLCsup-BM of splenic concanavalin CA blastogenesis was not dependent on cell contact since immunosuppression occurred regardless of whether the LLCsup-BM were separated from the responder spleen cells by a permeable membrane or if the LLCsup-BM were cocultured with the spleen cells. Culture supernatants of LLCsup-BM also inhibited T cell blastogenesis, being more suppressive than were supernatants of control bone marrow cells, which had been precultured with medium. The suppression by the soluble inhibitors elaborated from the LLCsup-BM was not restricted to the inhibition of T cell function as the supernatants also inhibited the natural killer activity of normal spleen cells. Studies to determine the identity of the suppressive activity produced by the LLCsup-BM showed increased levels of transforming growth factor beta (TGF beta) in their supernatants. Immunosuppressive bone marrow and spleen cells obtained from mice bearing metastatic LLC-LN7 tumors also secreted more TGF beta than did the cells obtained from normal mice. When anti-TGF beta antibodies were added to the LLCsup-BM supernatants, the suppressive activity was diminished. These results suggest that the LLCsup-BM mediate at least part of their immunosuppression through production of TGF beta. | lld:pubmed |
| pubmed-article:1535284 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1535284 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1535284 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1535284 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1535284 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1535284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1535284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1535284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1535284 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1535284 | pubmed:issn | 0340-7004 | lld:pubmed |
| pubmed-article:1535284 | pubmed:author | pubmed-author:YoungM RMR | lld:pubmed |
| pubmed-article:1535284 | pubmed:author | pubmed-author:YoungM EME | lld:pubmed |
| pubmed-article:1535284 | pubmed:author | pubmed-author:WrightM AMA | lld:pubmed |
| pubmed-article:1535284 | pubmed:author | pubmed-author:CooganMM | lld:pubmed |
| pubmed-article:1535284 | pubmed:author | pubmed-author:BagashJJ | lld:pubmed |
| pubmed-article:1535284 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1535284 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:1535284 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1535284 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1535284 | pubmed:pagination | 14-8 | lld:pubmed |
| pubmed-article:1535284 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1535284 | pubmed:meshHeading | pubmed-meshheading:1535284-... | lld:pubmed |
| pubmed-article:1535284 | pubmed:meshHeading | pubmed-meshheading:1535284-... | lld:pubmed |
| pubmed-article:1535284 | pubmed:meshHeading | pubmed-meshheading:1535284-... | lld:pubmed |
| pubmed-article:1535284 | pubmed:meshHeading | pubmed-meshheading:1535284-... | lld:pubmed |
| pubmed-article:1535284 | pubmed:meshHeading | pubmed-meshheading:1535284-... | lld:pubmed |
| pubmed-article:1535284 | pubmed:meshHeading | pubmed-meshheading:1535284-... | lld:pubmed |
| pubmed-article:1535284 | pubmed:meshHeading | pubmed-meshheading:1535284-... | lld:pubmed |
| pubmed-article:1535284 | pubmed:meshHeading | pubmed-meshheading:1535284-... | lld:pubmed |
| pubmed-article:1535284 | pubmed:meshHeading | pubmed-meshheading:1535284-... | lld:pubmed |
| pubmed-article:1535284 | pubmed:meshHeading | pubmed-meshheading:1535284-... | lld:pubmed |
| pubmed-article:1535284 | pubmed:meshHeading | pubmed-meshheading:1535284-... | lld:pubmed |
| pubmed-article:1535284 | pubmed:meshHeading | pubmed-meshheading:1535284-... | lld:pubmed |
| pubmed-article:1535284 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1535284 | pubmed:articleTitle | Tumor-derived cytokines induce bone marrow suppressor cells that mediate immunosuppression through transforming growth factor beta. | lld:pubmed |
| pubmed-article:1535284 | pubmed:affiliation | Department of Research Services, Hines V. A. Hospital, IL 60141. | lld:pubmed |
| pubmed-article:1535284 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1535284 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1535284 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1535284 | lld:pubmed |
