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pubmed-article:1535214pubmed:abstractTextThe effect of retinoids on the production of interleukin-1 (IL-1) by murine epidermal keratinocytes was investigated. Freshly isolated keratinocytes were cultured in the presence of etretinate, acitretin, all-trans retinoic acid or 13-cis retinoic acid at concentrations of 8 x 10(-9)-8 x 10(-6) mol/l. Exposure of keratinocytes to retinoids increased IL-1 bioactivity in culture supernatants and cell extracts at concentrations as low as 8 x 10(-9) mol/l, as assessed by T-cell proliferation. Prolongation of the culture period enhanced the augmentative effect of retinoids. All-trans retinoic acid and 13-cis retinoic acid had a greater ability to induce IL-1 production than the two aromatic retinoids, etretinate and acitretin. Treatment with 8-methoxypsoralen plus ultraviolet A radiation and treatment with triamcinolone acetonide both reduced the effect of retinoids on the production of bioactive IL-1.lld:pubmed
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pubmed-article:1535214pubmed:articleTitleRetinoid augmentation of bioactive interleukin-1 production by murine keratinocytes.lld:pubmed
pubmed-article:1535214pubmed:affiliationDepartment of Dermatology, Yale University School of Medicine, New Haven.lld:pubmed
pubmed-article:1535214pubmed:publicationTypeJournal Articlelld:pubmed
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