| pubmed-article:15350840 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15350840 | lifeskim:mentions | umls-concept:C0024554 | lld:lifeskim |
| pubmed-article:15350840 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15350840 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:15350840 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:15350840 | lifeskim:mentions | umls-concept:C1855073 | lld:lifeskim |
| pubmed-article:15350840 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15350840 | pubmed:dateCreated | 2004-9-7 | lld:pubmed |
| pubmed-article:15350840 | pubmed:abstractText | The aims of our study were to determine mortality, and age- and genotype-related cardiac phenotype in endothelial nitric oxide synthase (NOS) knockout (-/-) and wild-type (+/+) mice. Male and female (-/-) and male and female (+/+) conscious mice were studied at different ages by echocardiography and tail-cuff blood pressure (BP) measurement. Only 50% male (-/-) mice lived longer than 21 months whereas 89% (+/+) mice were still alive after 24 months (P < 0.005). There was little mortality in female mice of either genotype. Both (-/-) and (+/+) male mice have normal cardiac dimensions and function at 5.5 months. However, (-/-) mice developed cardiac dilation and dysfunction at 21 months as evidenced by a significant increase (P < 0.05) in left ventricular (LV) end-diastolic diameter from 2.69 +/- 0.13 to 3.13 +/- 0.09 mm, LV end-systolic diameter from 1.28 +/- 0.11 to 1.86 +/- 0.12 mm, LV end-diastolic cavity volume from 21 +/- 2.8 to 31 +/- 2.5 microl and LV mass from 19 +/- 2.5 to 27 +/- 1.9 mg/10 g and a significant decrease (P < 0.05) in ejection fraction (from 65 +/- 3.3% to 41 +/- 4.6%), shortening fraction (from 53 +/- 2.2% to 41 +/- 3.4%), LV posterior wall thickening (from 27 +/- 2% to 12 +/- 4%) and septum thickening (from 27 +/- 2% to 12 +/- 4%) compared with those at 5.5 months. There was a clear increase in cardiac weight and cardiac dilation by hematoxylin and eosin in male (-/-) mice at 21 months. BP in male (-/-) mice fell with the cardiac dysfunction, whereas female (-/-) mice were hypertensive even at 21 months. The level of mRNA for neuronal NOS and inducible NOS was greater in all females compared to males. These results indicate that male (-/-) mice have a significantly shorter lifespan than (+/+) or female mice, and male (-/-) mice develop cardiac dysfunction with age. | lld:pubmed |
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| pubmed-article:15350840 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15350840 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15350840 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15350840 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15350840 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15350840 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15350840 | pubmed:issn | 0022-2828 | lld:pubmed |
| pubmed-article:15350840 | pubmed:author | pubmed-author:FuY PYP | lld:pubmed |
| pubmed-article:15350840 | pubmed:author | pubmed-author:HintzeThomas... | lld:pubmed |
| pubmed-article:15350840 | pubmed:author | pubmed-author:KaleyGaborG | lld:pubmed |
| pubmed-article:15350840 | pubmed:author | pubmed-author:MitalSeemaS | lld:pubmed |
| pubmed-article:15350840 | pubmed:author | pubmed-author:CsiszarAnnaA | lld:pubmed |
| pubmed-article:15350840 | pubmed:author | pubmed-author:OjaimiCarolin... | lld:pubmed |
| pubmed-article:15350840 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15350840 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:15350840 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15350840 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15350840 | pubmed:pagination | 671-80 | lld:pubmed |
| pubmed-article:15350840 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15350840 | pubmed:meshHeading | pubmed-meshheading:15350840... | lld:pubmed |
| pubmed-article:15350840 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15350840 | pubmed:articleTitle | Premature death and age-related cardiac dysfunction in male eNOS-knockout mice. | lld:pubmed |
| pubmed-article:15350840 | pubmed:affiliation | Department of Physiology, New York Medical College, Valhalla, NY, USA. | lld:pubmed |
| pubmed-article:15350840 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15350840 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:18127 | entrezgene:pubmed | pubmed-article:15350840 | lld:entrezgene |
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