Linked Life Data

15349719

Source:http://linkedlifedata.com/resource/pubmed/id/15349719

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15349719rdf:typepubmed:Citationlld:pubmed
pubmed-article:15349719lifeskim:mentionsumls-concept:C0008109lld:lifeskim
pubmed-article:15349719lifeskim:mentionsumls-concept:C0034721lld:lifeskim
pubmed-article:15349719lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:15349719lifeskim:mentionsumls-concept:C1167395lld:lifeskim
pubmed-article:15349719lifeskim:mentionsumls-concept:C0023216lld:lifeskim
pubmed-article:15349719lifeskim:mentionsumls-concept:C0024203lld:lifeskim
pubmed-article:15349719lifeskim:mentionsumls-concept:C0018133lld:lifeskim
pubmed-article:15349719lifeskim:mentionsumls-concept:C0332152lld:lifeskim
pubmed-article:15349719lifeskim:mentionsumls-concept:C1292733lld:lifeskim
pubmed-article:15349719pubmed:issue7lld:pubmed
pubmed-article:15349719pubmed:dateCreated2004-9-6lld:pubmed
pubmed-article:15349719pubmed:abstractTextIn previous rat studies, the use of mixed allogeneic chimerism (MAC) to induce host tolerance to hind limb allografts has resulted in severe graft-versus-host disease (GVHD). The purpose of this study was to determine if immunocompetent cells in bone marrow (BM) and/or lymph nodes (LNs) of transplanted limbs were responsible for inducing GVHD in mixed chimeric hosts. [ACI-->Wistar Furth] chimeric rats received ACI hind limbs that were non-irradiated, irradiated (1050 cGy) or lymphadenectomized. Rejection, GVHD and donor chimerism was assessed. Chimeric hosts rejected none of their limbs. However, hosts of non-irradiated hind limbs succumbed to GVHD 22.4+/-0.8 days after transplantation. In contrast, chimeras that received irradiated or lymphadenectomized ACI hind limbs showed no clinical or histological signs of GVHD at 5 months. We conclude that mixed chimeric hosts are susceptible to GVHD due to the immunocompetent cell load provided by the LNs, not the BM, of hind limb allografts.lld:pubmed
pubmed-article:15349719pubmed:languageenglld:pubmed
pubmed-article:15349719pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15349719pubmed:citationSubsetIMlld:pubmed
pubmed-article:15349719pubmed:statusMEDLINElld:pubmed
pubmed-article:15349719pubmed:monthAuglld:pubmed
pubmed-article:15349719pubmed:issn0934-0874lld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:BarkerJohn...lld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:FrancoisCedri...lld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:MaldonadoClau...lld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:StadelmannWay...lld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:AndersonGary...lld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:KonMosheMlld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:HewittCharles...lld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:Perez-AbadiaG...lld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:GorantlaVijay...lld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:BrouhaPascal...lld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:TaiChauClld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:VossenMarieke...lld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:Laurentin-Per...lld:pubmed
pubmed-article:15349719pubmed:authorpubmed-author:PidwellDianeDlld:pubmed
pubmed-article:15349719pubmed:issnTypePrintlld:pubmed
pubmed-article:15349719pubmed:volume17lld:pubmed
pubmed-article:15349719pubmed:ownerNLMlld:pubmed
pubmed-article:15349719pubmed:authorsCompleteYlld:pubmed
pubmed-article:15349719pubmed:pagination341-50lld:pubmed
pubmed-article:15349719pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:meshHeadingpubmed-meshheading:15349719...lld:pubmed
pubmed-article:15349719pubmed:year2004lld:pubmed
pubmed-article:15349719pubmed:articleTitleLymphadenectomy prior to rat hind limb allotransplantation prevents graft-versus-host disease in chimeric hosts.lld:pubmed
pubmed-article:15349719pubmed:affiliationSurgery Department, University of Louisville, 320 MDR Building, 511 S. Floyd Street, Louisville, Kentucky, USA.lld:pubmed
pubmed-article:15349719pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15349719pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15349719lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15349719lld:pubmed