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| pubmed-article:15345450 | lifeskim:mentions | umls-concept:C0370215 | lld:lifeskim |
| pubmed-article:15345450 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:15345450 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:15345450 | lifeskim:mentions | umls-concept:C1705313 | lld:lifeskim |
| pubmed-article:15345450 | lifeskim:mentions | umls-concept:C1515273 | lld:lifeskim |
| pubmed-article:15345450 | lifeskim:mentions | umls-concept:C1521738 | lld:lifeskim |
| pubmed-article:15345450 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15345450 | pubmed:dateCreated | 2004-9-3 | lld:pubmed |
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| pubmed-article:15345450 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15345450 | pubmed:abstractText | Oxolinic acid (OA), a quinolone, inhibits the activity of DNA gyrase composed of GyrA and GyrB and shows antibacterial activity against Burkholderia glumae. Since B. glumae causes bacterial seedling rot and grain rot of rice, both of which are devastating diseases, the emergence of OA-resistant bacteria has important implications on rice cultivation in Japan. Based on the MIC of OA, 35 B. glumae field isolates isolated from rice seedlings grown from OA-treated seeds in Japan were divided into sensitive isolates (OSs; 0.5 microg/ml), moderately resistant isolates (MRs; 50 microg/ml), and highly resistant isolates (HRs; > or =100 microg/ml). Recombination with gyrA of an OS, Pg-10, led MRs and HRs to become OA susceptible, suggesting that gyrA mutations are involved in the OA resistance of field isolates. The amino acid at position 83 in the GyrA of all OSs was Ser, but in all MRs and HRs it was Arg and Ile, respectively. Ser83Arg and Ser83Ile substitutions in the GyrA of an OS, Pg-10, resulted in moderate and high OA resistance, respectively. Moreover, Arg83Ser and Ile83Ser substitutions in the GyrA of MRs and HRs, respectively, resulted in susceptibility to OA. These results suggest that Ser83Arg and Ser83Ile substitutions in GyrA are commonly responsible for resistance to OA in B. glumae field isolates. | lld:pubmed |
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| pubmed-article:15345450 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15345450 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15345450 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15345450 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15345450 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15345450 | pubmed:issn | 0099-2240 | lld:pubmed |
| pubmed-article:15345450 | pubmed:author | pubmed-author:OhnishiKouhei... | lld:pubmed |
| pubmed-article:15345450 | pubmed:author | pubmed-author:HikichiYasufu... | lld:pubmed |
| pubmed-article:15345450 | pubmed:author | pubmed-author:KibaAkinoriA | lld:pubmed |
| pubmed-article:15345450 | pubmed:author | pubmed-author:MaedaYukikoY | lld:pubmed |
| pubmed-article:15345450 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15345450 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:15345450 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15345450 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15345450 | pubmed:pagination | 5613-20 | lld:pubmed |
| pubmed-article:15345450 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15345450 | pubmed:meshHeading | pubmed-meshheading:15345450... | lld:pubmed |
| pubmed-article:15345450 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15345450 | pubmed:articleTitle | Implications of amino acid substitutions in GyrA at position 83 in terms of oxolinic acid resistance in field isolates of Burkholderia glumae, a causal agent of bacterial seedling rot and grain rot of rice. | lld:pubmed |
| pubmed-article:15345450 | pubmed:affiliation | Laboratory of Plant Pathology and Biotechnology, Kochi University, 200 Monobe, Nankoku, Kochi 783-8502, Japan. | lld:pubmed |
| pubmed-article:15345450 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15345450 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15345450 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15345450 | lld:pubmed |
